SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator.

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Abstract

Our previous study revealed the immunomodulatory property of the secreted lymphocyte antigen (Ly6)/urokinase-type plasminogen activator receptor (uPAR)-related protein-1 (SLURP1), abundantly expressed in the cornea and associated with the hyperkeratotic disorder Mal de Meleda. Here, we test the hypothesis that SLURP1 modulates the functions of membrane-tethered uPAR by acting as a soluble scavenger of its ligand urokinase-type plasminogen activator (uPA).

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Author and article information

Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Aug 28 2014

Volume: 55

Issue: 10

Affiliations

[1 ] Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

Article

Publisher Item ID: iovs.14-15107

DOI: 10.1167/iovs.14-15107

PMC ID: 4183074

PubMed ID: 25168896

SO-VID: 535ebfb2-9ebc-4da8-bcef-87d890549c9b

History

Keywords: cornea,uPAR,urokinase,Slurp1,uPA,ocular surface,migration

Data availability:

Keywords: cornea, uPAR, urokinase, Slurp1, uPA, ocular surface, migration

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