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      Dissemination of the multidrug-resistant extended-spectrum β-lactamase-producing Escherichia coli O25b-ST131 clone and the role of house crow (Corvus splendens) foraging on hospital waste in Bangladesh.

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          Abstract

          Two hundred and thirty-eight faecal samples from crows foraging on hospital wastes were analysed for extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. ESBL-producing crow isolates were characterized and compared with 31 patient isolates. Among the crows, 59% carried ESBL producers. These included Escherichia coli, Klebsiella pneumoniae, Raoultella terrigena and Enterobacter cloacae harbouring the genes for CTX-M-1, CTX-M-15, CTX-M-55, CTX-M-79, and CTX-M-14. Human isolates carried only the CTX-M-15 gene. Two-thirds of crow E. coli isolates and all human E. coli isolates were multidrug resistant. Crows and patients shared E. coli sequence types, including the epidemic E. coli O25b-ST131 clone. The scavenging behaviour of crows at poorly managed hospital waste dumps made them potential reservoirs of antibiotic resistance, including ESBLs.

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          Author and article information

          Journal
          Clin. Microbiol. Infect.
          Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
          1469-0691
          1198-743X
          Nov 2015
          : 21
          : 11
          Affiliations
          [1 ] Clinical Microbiology and Infectious Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden. Electronic address: badrul.hasan@medsci.uu.se.
          [2 ] Clinical Microbiology and Infectious Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, BMC, Uppsala University, Uppsala, Sweden.
          [3 ] Rajshahi Medical College Hospital, Rajshahi, Bangladesh.
          [4 ] Chittagong Medical College Hospital, Chittagong, Bangladesh.
          [5 ] Clinical Microbiology and Infectious Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
          Article
          S1198-743X(15)00661-8
          10.1016/j.cmi.2015.06.016
          26115863
          5369e2a8-ad62-4112-b878-9cdefa11b44b
          Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
          History

          E. coli,O25b-ST131,bla(CTX-M-15),hospital waste,house crow
          E. coli, O25b-ST131, bla(CTX-M-15), hospital waste, house crow

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