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      Development of simple analytical methods of polychlorinated biphenyls in human serum by gas chromatography negative ion chemical ionization quadrupole mass spectrometry

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          Abstract

          In this study, we developed a highly sensitive, robust method for determining 12 congeners of two to ten chlorinated polychlorinated biphenyls (PCBs) in serum samples using gas chromatography (GC)–mass spectrometry (MS) operating in selected ion monitoring mode (SIM: m/ z 35) with negative ion chemical ionization (NICI), and the results were compared with those from GC coupled with high-resolution MS (HRMS) with electron impact (EI). The recovery rates of the surrogate PCB congeners were 97.2%–112% (coefficient of variation: 5.3%–8.5%), and the method detection limits for PCBs in each matrix obtained by GC–NICI–quadrupole mass spectrometry (qMS) were 1.9–20 pg g −1 wet wt. The analytical values of the target compounds in the samples analyzed by GC–NICI–qMS and GC–EI–HRMS were comparable (Passing–Bablok regression: R = 0.888–0.967), and the analytical values obtained via GC–NICI–qMS were almost comparable with those of the certified serum samples from National Institute of Standards and Technology (NIST: SRM1957), indicating that GC–NICI–qMS is suitable for the analysis of tetra- to hepta-chlorinated PCBs in serum samples.

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          Author and article information

          Journal
          1326
          Acta Chromatographica
          Acta Chromatographica
          Akadémiai Kiadó
          2083-5736
          December 2017
          : 29
          : 4
          : 503-506
          Affiliations
          [ 1 ] Chiba University, Center for Preventive Medical Sciences, Inage-ku Yayoi-cho 1-33 , Chiba City 263-0022, Japan
          [ 2 ]JEOL Ltd., 1156 Nakagami-cho, Akishima, Tokyo 196-0022, Japan
          [ 3 ] Chiba University , Department of Bioenvironmental Medicine, Graduate School of Medicine, Chuo-ku Inohana 1-8-1, Chiba City 260-8670, Japan
          Author notes
          [*]

          Author for correspondence: cmori@ 123456faculty.chiba-u.jp

          Article
          10.1556/1326.2017.00029
          53710681-5afb-46ff-923e-c44c4ba99f7b
          © 2017 The Author(s)

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited.

          History
          : 9 May 2017
          : 05 April 2016
          : 12 May 2016
          Page count
          Pages: 4
          Categories
          Original Research Paper

          Materials properties,Nanomaterials,Chemistry,Nanotechnology,Analytical chemistry,Thin films & surfaces
          PCBs,GC–MS,negative ion chemical ionization,serum

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