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      The human tumor microbiome is composed of tumor type–specific intracellular bacteria

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      Science
      American Association for the Advancement of Science (AAAS)

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          Abstract

          Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients’ smoking status, and the response to immunotherapy.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          May 28 2020
          May 29 2020
          May 28 2020
          May 29 2020
          : 368
          : 6494
          : 973-980
          Affiliations
          [1 ]Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
          [2 ]Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
          [3 ]Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
          [4 ]Division of Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
          [5 ]Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
          [6 ]Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
          [7 ]Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.
          [8 ]Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
          [9 ]Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
          [10 ]Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
          [11 ]Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel.
          [12 ]Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.
          [13 ]Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
          [14 ]Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
          [15 ]Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
          [16 ]Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel.
          [17 ]Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel.
          [18 ]Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
          [19 ]Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel.
          [20 ]Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
          [21 ]Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.
          [22 ]Division of General Surgery, Rambam Health Care Campus, Haifa, Israel.
          [23 ]Ambulatory and Breast Surgery Service, Rambam Health Care Campus, Haifa, Israel.
          [24 ]Department of Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel.
          [25 ]Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel.
          [26 ]Department of Neurosurgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
          [27 ]Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
          [28 ]Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel.
          [29 ]Breast Oncology Institute, Sheba Medical Center, Ramat Gan, Israel.
          [30 ]Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
          [31 ]Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
          [32 ]Department of Surgical Oncology (Surgery C), Sheba Medical Center, Ramat Gan, Israel.
          [33 ]Department of Pathology, Sheba Medical Center, Ramat Gan, Israel.
          [34 ]Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.
          [35 ]Division of Thoracic Surgery, City of Hope Medical Center, Duarte, CA, USA.
          [36 ]Department of Mathematics and Computer Science, The Open University of Israel, Ra’anana, Israel.
          Article
          10.1126/science.aay9189
          7757858
          32467386
          537823f8-5bf4-4a03-97ca-b1044c0cb620
          © 2020

          http://www.sciencemag.org/about/science-licenses-journal-article-reuse

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