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      2019 EACTS Expert Consensus on long-term mechanical circulatory support

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          Abstract

          Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for patients with severe heart failure. Different devices are available, and many—sometimes contradictory—observations regarding patient selection, surgical techniques, perioperative management and follow-up have been published. With the growing expertise in this field, the European Association for Cardio-Thoracic Surgery (EACTS) recognized a need for a structured multidisciplinary consensus about the approach to patients with LT-MCS. However, the evidence published so far is insufficient to allow for generation of meaningful guidelines complying with EACTS requirements. Instead, the EACTS presents an expert opinion in the LT-MCS field. This expert opinion addresses patient evaluation and preoperative optimization as well as management of cardiac and non-cardiac comorbidities. Further, extensive operative implantation techniques are summarized and evaluated by leading experts, depending on both patient characteristics and device selection. The faculty recognized that postoperative management is multidisciplinary and includes aspects of intensive care unit stay, rehabilitation, ambulatory care, myocardial recovery and end-of-life care and mirrored this fact in this paper. Additionally, the opinions of experts on diagnosis and management of adverse events including bleeding, cerebrovascular accidents and device malfunction are presented. In this expert consensus, the evidence for the complete management from patient selection to end-of-life care is carefully reviewed with the aim of guiding clinicians in optimizing management of patients considered for or supported by an LT-MCS device.

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          Most cited references470

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          Biomarkers in heart failure.

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            Eighth annual INTERMACS report: Special focus on framing the impact of adverse events.

            The Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database now includes >20,000 patients from >180 hospitals.
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              The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary.

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                Author and article information

                Journal
                Eur J Cardiothorac Surg
                Eur J Cardiothorac Surg
                ejcts
                European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
                Oxford University Press
                1010-7940
                1873-734X
                August 2019
                17 May 2019
                17 May 2019
                : 56
                : 2
                : 230-270
                Affiliations
                [1 ]Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany
                [2 ]Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands
                [3 ]Complexo Hospitalario Universitario A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), CIBERCV, UDC, La Coruña, Spain
                [4 ]Sorbonne Université, INSERM, Institute of Cardiometabolism and Nutrition, Paris, France
                [5 ]Service de médecine intensive-réanimation, Institut de Cardiologie, APHP, Hôpital Pitié–Salpêtrière, Paris, France
                [6 ]Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University of Jena, Jena, Germany
                [7 ]Department of Medical Microbiology, University College of Dublin, Dublin, Ireland
                [8 ]Department of Anaesthesiology, German Heart Center Berlin, Berlin, Germany
                [9 ]Department of Cardiology, University Medical Center Utrecht, Utrecht, Netherlands
                [10 ]Department of Cardiothoracic, S. Orsola Hospital, Transplantation and Vascular Surgery, University of Bologna, Bologna, Italy
                [11 ]Department of Medicine Karolinska Institute, Heart and Vascular Theme, Karolinska University Hospital, Solna, Sweden
                [12 ]Department of Cardiovascular Surgery Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland
                [13 ]Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Germany
                [14 ]Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic
                [15 ]Department of Cardiovascular Surgery, Ege University, Izmir, Turkey
                [16 ]Advanced Heart Failure and Mechanical Circulatory Support Program, Cardiac Intensive Care, San Raffaele Hospital, Vita Salute University, Milan, Italy
                [17 ]Department of Anesthesia and Intensive Care, San Raffaele Hospital, Vita Salute University, Milan, Italy
                [18 ]Department of Congenital Pediatric Surgery, Zurich Children's Hospital, Zurich, Switzerland
                [19 ]Royal Papworth Hospital, Cambridge, United Kingdom
                [20 ]Department of Surgery, Division of Cardiac Surgery, Medical University of Vienna, Vienna, Austria
                [21 ]Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
                Author notes

                Evgenij V Potapov and Christiaan Antonides first two authors contributed equally to this study.

                Corresponding authors. Department of Cardiothoracic Surgery, German Heart Centre Berlin, Berlin, Germany. Tel: 49-30-4593 2065; e-mail: potapov@ 123456dhzb.de (E.V. Potapov); Department of Cardiology, Rigshospitalet, 9 Blegdamsvej, 2100 Copenhagen, Denmark. Tel: +45-35-459743; e-mail: finng@ 123456dadlnet.dk (F. Gustafsson).
                Article
                ezz098
                10.1093/ejcts/ezz098
                6640909
                31100109
                537ca3f7-68d2-4c07-aa64-a271cde5e5b1
                © The Author(s) 2019. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                Page count
                Pages: 41
                Categories
                Reports
                Eacts/22
                Eacts/27
                Editor's Choice

                Surgery
                mechanical circulatory support,left ventricular assist devices,heart failure,expert consensus

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