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      Journal of Pain Research (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on reporting of high-quality laboratory and clinical findings in all fields of pain research and the prevention and management of pain. Sign up for email alerts here.

      52,235 Monthly downloads/views I 2.832 Impact Factor I 4.5 CiteScore I 1.2 Source Normalized Impact per Paper (SNIP) I 0.655 Scimago Journal & Country Rank (SJR)

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      Profile of extended-release oxycodone/acetaminophen for acute pain

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          Abstract

          This article provides a historical and pharmacological overview of a new opioid analgesic that boasts an extended-release (ER) formulation designed to provide both immediate and prolonged analgesia for up to 12 hours in patients who are experiencing acute pain. This novel medication, ER oxycodone/acetaminophen, competes with current US Food and Drug Administration (FDA)-approved opioid formulations available on the market in that it offers two benefits concurrently: a prolonged duration of action, and multimodal analgesia through a combination of an opioid (oxycodone) with a nonopioid component. Current FDA-approved combination analgesics, such as Percocet (oxycodone/acetaminophen), are available solely in immediate-release (IR) formulations.

          Most cited references12

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          RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH

          Lee S. Simon (2012)
          Article 0 comments Cited 108 times – based on 0 reviews     Review now
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            The effect of opioid therapy on endocrine function.

            Michael Brennan (2013)
            Opioids are an established option in the analgesic armamentarium for managing moderate-to-severe chronic pain. Long-term opioid use, however, is associated with several potential adverse effects and toxicities, such as peripheral edema, immune suppression, hyperalgesia, sleep apnea, and changes in endocrine function, many of which are not fully appreciated. Opioid endocrinopathy can greatly affect patients, causing reduced sexual function, decreased libido, infertility, mood disorders, osteoporosis, and osteopenia. Furthermore, although opioid endocrinopathy appears to be common, many patients do not report their symptoms, thus causing this adverse effect to go unnoticed and without clinical monitoring, particularly in patients chronically taking the equivalent of ≥ 100 mg of morphine daily. Indeed, diagnosing hypogonadism as opioid-related can be challenged by other influences on endocrine function, such as pain pathophysiology, comorbidities, other drug therapies, and patient age. Management options for opioid endocrinopathy include discontinuing opioid therapy, reducing the opioid dose, switching to a different opioid, and hormone supplementation. Copyright © 2013 Elsevier Inc. All rights reserved.
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              Tramadol-induced adrenal insufficiency.

              Sandra S. Chan, Christen Rolfe, M Debono … (2011)
              Article 0 comments Cited 11 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Pain Res
                Journal ID (iso-abbrev): J Pain Res
                Journal ID (publisher-id): Journal of Pain Research
                Title: Journal of Pain Research
                Publisher: Dove Medical Press
                ISSN (Electronic): 1178-7090
                Publication date Collection: 2015
                Publication date (Electronic): 21 October 2015
                Volume: 8
                Pages: 719-728
                Affiliations
                [1 ]David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
                [2 ]Ronald Reagan UCLA Medical Center, University of California Los Angeles, Los Angeles, CA, USA
                [3 ]UCLA Ambulatory Surgery Center, University of California Los Angeles, Los Angeles, CA, USA
                [4 ]UCLA Wasserman Eye Institute, University of California Los Angeles, Los Angeles, CA, USA
                [5 ]UCLA Martin Luther King Community Hospital, University of California Los Angeles, Los Angeles, CA, USA
                Author notes
                Correspondence: Mary Hanna Bekhit, Department of Anesthesiology David Geffen School of Medicine University of California, Los Angeles 757 Westwood Plaza, Suite 2331 Los Angeles, CA 90095, USA, Tel +1 310 825 6301, Email mbekhit@ 123456mednet.ucla.edu
                Article
                Publisher ID: jpr-8-719
                DOI: 10.2147/JPR.S73567
                PMC ID: 4621217
                SO-VID: 538b7982-363c-4885-aa98-319158daffb8
                Copyright © © 2015 Bekhit. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License
                License:

                The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Subject: Review

                ScienceOpen disciplines: Anesthesiology & Pain management
                Keywords: opioid,analgesic,xartemis,acute postsurgical pain,substance abuse,acetaminophen,extended release
                Data availability:
                ScienceOpen disciplines: Anesthesiology & Pain management
                Keywords: opioid, analgesic, xartemis, acute postsurgical pain, substance abuse, acetaminophen, extended release

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