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      Heterogeneity of Capillary Perfusion

      Journal of Vascular Research

      S. Karger AG

      Heterogeneity, Microvascular networks, Topology, Angioarchitecture

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          Abstract

          Heterogeneity represents a general feature of capillary networks. All of the parameters which describe hemodynamic, geometric or functional aspects of such networks exhibit considerable spatial dispersion. This is to some extent the result of the morphological and topological design of the network, reinforced by the nonhomogeneous nature of the flowing blood. Temporal dispersions are introduced by smooth muscle activity, which may be rhythmic or just oscillatory, but also by the passage of white cells causing transient perturbations. The functional relevance of perfusion heterogeneity follows from its effect on exchange efficiency. While evidence for the existence of physiological control mechanisms of heterogeneity is uncertain, intranetwork communication between upstream and downstream vessel segments appears to support the adaptation of supply to demand under physiological conditions.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-5380-3
          978-3-318-01726-7
          1018-1172
          1423-0135
          1991
          1991
          23 September 2008
          : 28
          : 1-3
          : 197-200
          Affiliations
          Institut für Physiologie, Freie Universität Berlin, FRG
          Article
          158862 Blood Vessels 1991;28:197–200
          10.1159/000158862
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Physiology and Pathophysiology

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