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      Cumulative live birth and surplus embryo incidence after frozen-thaw cycles in PCOS: how many oocytes do we need?

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          Abstract

          Purpose

          This study aimed to evaluate the cumulative live birth rate (CLBR) and surplus embryo rate of polycystic ovarian syndrome (PCOS) patients during in vitro fertilization and embryo transfer (IVF-ET) treatment.

          Methods

          In this retrospective cohort study, we analyzed 1142 PCOS patients who underwent first IVF in our institution between January 2011 and December 2014. All patients were categorized into five groups according to the number of oocytes retrieved. Main outcomes include CLBR and surplus embryo rate.

          Results

          A strong correlation was observed between number of oocytes retrieved and CLBR as well as surplus embryo rate in PCOS patients. CLBR was elevated with the increasing number of oocytes and plateaued when oocyte number was up to ten, whereas the surplus embryo rate steadily increased in line with the increase of oocyte number. Patients transferred with frozen embryos showed higher CLBR and LBR during first ET than patients transferred with fresh embryos.

          Conclusions

          For PCOS patients, retrieving more than ten oocytes leads to no significant benefit to CLBR but generates surplus embryos. Thus, moderate ovarian stimulation should be reconsidered during IVF treatment.

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          Author and article information

          Contributors
          chenyuanhui1119@163.com
          wqian0920@163.com
          18838295571@163.com
          15837109752@163.com
          470070665@qq.com
          luckyzcl@qq.com
          Journal
          J Assist Reprod Genet
          J. Assist. Reprod. Genet
          Journal of Assisted Reproduction and Genetics
          Springer US (New York )
          1058-0468
          1573-7330
          3 June 2017
          September 2017
          : 34
          : 9
          : 1153-1159
          Affiliations
          [1 ] GRID grid.414011.1, Reproductive Medical Center, , Henan Provincial People’s Hospital, ; Weiwu Road, Zhengzhou, 450003 Henan Province People’s Republic of China
          [2 ] GRID grid.414011.1, Reproductive Medical Center, , People’s Hospital of Zhengzhou University, ; Weiwu Road, Zhengzhou, 450003 Henan Province People’s Republic of China
          Article
          PMC5581780 PMC5581780 5581780 959
          10.1007/s10815-017-0959-6
          5581780
          28580513
          © Springer Science+Business Media New York 2017
          Categories
          Assisted Reproduction Technologies
          Custom metadata
          © Springer Science+Business Media, LLC 2017

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