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Cardiac‐Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers

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      Most cited references 181

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      Heart disease and stroke statistics--2015 update: a report from the American Heart Association.

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        TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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          Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.

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            Author and article information

            Affiliations
            [ 1 ] Division of Cardiovascular Medicine Department of Internal Medicine and François M. Abboud Cardiovascular Research CenterUniversity of Iowa Carver College of Medicine Iowa City IA
            [ 2 ] Fraternal Order of Eagles Diabetes Research Center Papajohn Biomedical Institute Roy J. and Lucille A. Carver College of MedicineUniversity of Iowa Iowa City IA
            Author notes
            [* ] Correspondence to: Chad E. Grueter, PhD, University of Iowa, 4332 Pappajohn Biomedical Discovery Bldg, Iowa City, IA 52242. E‐mail: chad-grueter@ 123456uiowa.edu
            Journal
            J Am Heart Assoc
            J Am Heart Assoc
            10.1002/(ISSN)2047-9980
            JAH3
            ahaoa
            Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
            John Wiley and Sons Inc. (Hoboken )
            2047-9980
            31 May 2016
            June 2016
            : 5
            : 6 ( doiID: 10.1002/jah3.2016.5.issue-6 )
            27247337 4937259 10.1161/JAHA.115.003101 JAH31539
            © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

            This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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            Pages: 14
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            Funding
            Funded by: American Heart Association
            Award ID: 13SDG14660064
            Funded by: National Institutes of Health
            Funded by: National Heart, Lung and Blood Institute National Research Service Award Training
            Award ID: 5T32HL007121‐39
            Categories
            Basic Science for Clinicians
            Basic Science for Clinicians
            Custom metadata
            2.0
            jah31539
            June 2016
            Converter:WILEY_ML3GV2_TO_NLMPMC version:4.9.1 mode:remove_FC converted:28.06.2016

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