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Abstract
Considerable progress has been made towards understanding the function of thrombospondin-1
and-2. The description of the phenotype of mice with thrombospondin-1 and-2 knocked-out
supports in vitro biochemical and cell-biological data and has opened new avenues
of research. Recently, our understanding of the roles of thrombospondins in the activation
of TGFbeta, inhibition of angiogenesis and the initiation of signal transduction has
advanced.