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      Corneal Epithelial Changes in Diabetic Rats

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          Electron microscopy of streptozotocín diabetic rat eyes showed increased intracellular levels of tonofilaments and glycogen, thickenings and infoldings of subepithelial basement membrane and basal cell degeneration after 8 months. Glycogen, glucose, sorbitol, and fructose were measured in corneal epithelium from short- and long-term diabetic rats. The small increase in sorbitol pathway products which were found after 8 months of diabetes (less than 1.0 mosm/1 tissue water) confirmed similar findings in rabbits and humans. Thus, the morphologic changes occur in the absence of significant accumulation of sorbitol pathway products. Osmotic damage secondary to corneal epithelial cell accumulation of sorbitol is probably not a significant factor in corneal epithelial diabetic disease.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 14
          : 4
          : 269-278
          Eye Research Institute of Retina Foundation, Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Mass., USA
          265202 Ophthalmic Res 1982;14:269–278
          © 1982 S. Karger AG, Basel

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          Pages: 10
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