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      Contact-dependent inhibition: bacterial brakes and secret handshakes.

      Trends in Microbiology

      Signal Transduction, physiology, genetics, Membrane Proteins, Gene Expression Regulation, Bacterial, Escherichia coli Proteins, growth & development, Escherichia coli

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          Abstract

          Interbacterial communication can be mediated by soluble secreted factors and direct cell-cell contact. Recently, Aoki et al. identified a new contact-dependent communication pathway by which strains of uropathogenic Escherichia coli can inhibit the growth of other microbes within a mixed population. Two novel gene products--CdiA and CdiB, which seem to be members of a two-partner secretion family with homologs in many pathogens--mediate this contact-dependent inhibition (CDI). A third gene product, CdiI, provides immunity to CDI, as does expression of either P or S pili. The interplay between CDI and immunity factors could directly affect the course of an infection and modulate both the dispersion and the chronic persistence of bacterial pathogens within the host.

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          Journal
          10.1016/j.tim.2005.12.003
          16387500

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