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      The use of ancient DNA in paleontological studies

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      Journal of Vertebrate Paleontology

      Informa UK Limited

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          Most cited references 123

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          Instability and decay of the primary structure of DNA.

           T Lindahl (1993)
          Although DNA is the carrier of genetic information, it has limited chemical stability. Hydrolysis, oxidation and nonenzymatic methylation of DNA occur at significant rates in vivo, and are counteracted by specific DNA repair processes. The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.
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            Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia

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              [21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

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                Author and article information

                Journal
                Journal of Vertebrate Paleontology
                Journal of Vertebrate Paleontology
                Informa UK Limited
                0272-4634
                1937-2809
                March 15 1999
                March 15 1999
                : 19
                : 1
                : 8-20
                Article
                10.1080/02724634.1999.10011118
                © 1999

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