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      Patient Preference and Adherence (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on the growing importance of patient preference and adherence throughout the therapeutic process. Sign up for email alerts here.

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      A survey of patient preferences for a placebo orodispersible tablet

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          Abstract

          Aim

          To assess the attitudes and preferences of patients currently being treated for depression or anxiety disorders with traditional oral antidepressants relative to a placebo orodispersible (ODT) formulation of escitalopram.

          Methods

          This was an open study collecting patient-reported outcome data from patients with anxiety or depression that were treated with oral antidepressant medication on Day 0 before and after receiving a single placebo ODT, and on Day 3 or 4 after receiving two further daily doses of placebo ODT. Patients aged 18–80 years who were currently receiving treatment with oral antidepressants were recruited from general practice and by advertising. Patients with significant symptoms of anxiety or depression (scoring ≥9 on either the depression or anxiety subscales of the Hospital Anxiety and Depression Scale) were included in the study.

          Results

          A total of 150 patients were enrolled in and completed the study. About 37% of the patients had had trouble with swallowing tablets, and patients with higher depression scores reported more general swallowing problems than those with lower scores ( P = 0.002). Most patients (75.3%) believed that an ODT might work faster but that it would make no difference to the effectiveness of the medication (63.1%) or the number of side effects (81.3%). About 96% of the patients reported experiencing a pleasant taste following the placebo ODT, although seven patients did not like its taste or aftertaste. This study found that 80.7% of patients reported that the tablets were easy or very easy to get out of the packaging.

          Conclusion

          Based on the results of the placebo version of escitalopram ODT, the escitalopram ODT is likely to be well accepted by patients suffering from anxiety or depressive symptoms.

          Author and article information

          Journal
          Patient Prefer Adherence
          Patient Prefer Adherence
          Patient preference and adherence
          Dove Medical Press
          1177-889X
          2012
          20 March 2012
          : 6
          : 201-206
          Affiliations
          [1 ]CPS Research, Glasgow, UK
          [2 ]Department of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland, UK
          Author notes
          Correspondence: Alan G Wade, CPS Research, 3 Todd Campus, West of Scotland Science Park, Acre Road, Glasgow, G20 0XA, Scotland, UK, Tel +44 141 946 7888, Fax +44 141 946 1324, Email alangwade@ 123456fastmail.fm
          Article
          ppa-6-201
          10.2147/PPA.S28283
          3333815
          22536056
          53d71c24-b496-4034-b12c-418f2c3a9c86
          © 2012 Wade et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          History
          Categories
          Original Research

          Medicine
          anxiety,antidepressant,depression,odt,swallowing difficulties
          Medicine
          anxiety, antidepressant, depression, odt, swallowing difficulties

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