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      Distribution and Kinetics of the Inflammatory Cell Response to Ocular Challenge with Pseudomonas aeruginosa in Susceptible versus Resistant Mice

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          Abstract

          This study examined and characterized the distribution and kinetics of the inflammatory cell response to pseudomonas ocular challenge in susceptible C57BL/6J and resistant DBA/2J mice. Initially, in the cornea, the number of neutrophilic leukocytes (PMNs), macrophages/monocytes or lymphocytes was 2–2.5 times greater in resistant versus susceptible mice. The peak cellular response in the cornea was also greater in resistant than in susceptible animals. Further, resistant mice, when compared with susceptible mice, had a shorter duration of inflammatory cells as well as bacteria in the cornea. These data were similar for the cell infiltrate in the anterior chamber, with the exception that PMNs were initially greater in number in C57BL/6J than in DBA/2J mice. Collectively these data suggest that susceptible mice are, in general, cellularly hyporesponsive to pseudomonas ocular challenge when compared with resistant animals. This, together with persistence of inflammatory cells and bacteria in the cornea of susceptible animals, may contribute to their failure to restore corneal clarity following pseudomonas ocular challenge.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1992
          1992
          10 December 2009
          : 24
          : 1
          : 32-39
          Affiliations
          Departments of aAnatomy and Cell Biology and bImmunology and Microbiology, Wayne State University, School of Medicine, Detroit, Mich., USA
          Article
          267142 Ophthalmic Res 1992;24:32–39
          10.1159/000267142
          1608590
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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