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      Dietary-induced metabolic acidosis decreases bone mineral density in mature ovariectomized ewes.

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          Abstract

          Dietary-induced metabolic acidosis (DIMA) may be a significant confounder in the development of osteoporosis. Diets that are acidifying are typically rich in proteins and grains and relatively poor in fruits and vegetables. Previous studies have not examined whether an interaction between estrogen depletion and DIMA have a compounded affect on bone mineral density loss. Sheep have been used successfully in previous studies to examine the interaction of bone turnover and ovariectomy. Therefore, the goal of this pilot study was to determine if bone mineral density (BMD) loss could be induced using DIMA in skeletally mature ovariectomized (OVX) ewes.

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          Author and article information

          Journal
          Calcif. Tissue Int.
          Calcified tissue international
          Springer Nature America, Inc
          0171-967X
          0171-967X
          Nov 2004
          : 75
          : 5
          Affiliations
          [1 ] Department of Clinical Science, Colorado State University, Fort Collins, CO 80523, USA. JMacLeay@colostate.edu
          Article
          10.1007/s00223-004-0217-7
          15592799
          53e8f6b8-9853-4a62-a46e-924153ec6d67
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