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      Operational and implementation research within Global Fund to Fight AIDS, Tuberculosis and Malaria grants: a situation analysis in six countries

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          Abstract

          Background

          Operational/implementation research (OR/IR) is a key activity to improve disease control programme performance. We assessed the extent to which malaria and tuberculosis (TB) grants from the Global Fund to Fight AIDS, Tuberculosis and Malaria (“Global Fund”) include support for OR/IR, and discuss the implications of the current Global Fund operating mechanisms for OR/IR support.

          Methods

          The situation analysis focussed on malaria and TB, while HIV was excluded. Stakeholder interviews were conducted at the Global Fund secretariat and in six purposefully selected high disease burden countries, namely the Democratic Republic of the Congo, Ethiopia, India, Indonesia, Myanmar and Zimbabwe. Interviewed in-country stakeholders included the relevant disease control programme managers, project implementation partners, representatives from international organisations with a stake in global health, academic and governmental research institutions, and other relevant individuals such as members of the country coordination mechanism. Additionally, documentation of grants and OR/IR obtained from the Global Fund was reviewed.

          Results

          The Global Fund provides substantial resources for malaria and TB surveys, and supports OR/IR if such support is requested and the application is well justified. We observed considerable variations from one country to another and between programmes with regards to need, demand, absorption capacity and funding for OR/IR related to malaria and TB. Important determinants for the extent of such funding are the involvement of national research coordination bodies, established research agendas and priorities, human and technical research capacity, and involvement of relevant stakeholders in concept note development. Efforts to disseminate OR/IR findings were generally weak, and the Global Fund does not maintain a central OR/IR database. When faced with a need to choose between procurement of commodities for disease control and supporting research, countries tend to seek research funding from other donors. The Global Fund is expected to issue more specific guidance on the conditions under which it supports OR/IR, and to adapt administrative procedures to facilitate research.

          Conclusions

          The importance of OR/IR for optimising disease control programmes is generally accepted but countries vary in their capacity to demand and implement studies. Countries expect guidance on OR/IR from the Global Fund. Administrative procedures specifically related to the budget planning should be modified to facilitate ad-hoc OR/IR funding. More generally, several countries expressed a need to strengthen capacity for planning, negotiating and implementing research.

          Electronic supplementary material

          The online version of this article (doi:10.1186/s12992-017-0245-5) contains supplementary material, which is available to authorized users.

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          Most cited references17

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          Operational research in low-income countries: what, why, and how?

          Operational research is increasingly being discussed at institutional meetings, donor forums, and scientific conferences, but limited published information exists on its role from a disease-control and programme perspective. We suggest a definition of operational research, clarify its relevance to infectious-disease control programmes, and describe some of the enabling factors and challenges for its integration into programme settings. Particularly in areas where the disease burden is high and resources and time are limited, investment in operational research and promotion of a culture of inquiry are needed so that health care can become more efficient. Thus, research capacity needs to be developed, specific resources allocated, and different stakeholders (academic institutions, national programme managers, and non-governmental organisations) brought together in promoting operational research.
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            Strengthening health systems through embedded research

            Realizing the health-related sustainable development goals (SDGs) requires integrated action on system-wide challenges. To address gaps in health service delivery, we need evidence on which government agencies, research institutions, donors and civil society can act. 1 Unless research is relevant to specific health systems, the evidence that it generates can be dismissed by policy-makers. 2 For example, there is plenty of evidence for the effectiveness of standard interventions to prevent maternal and child deaths, but countries vary widely in the degree to which these interventions have been implemented. 3 We argue that embedding of research in real world policy, practice and implementation is needed to strengthen health systems worldwide. Embedded research conducted in partnership with policy-makers and implementers, integrated in different health system settings and that takes into account context-specific factors can ensure greater relevance in policy priority-setting and decision-making. 4 Collaboration between researchers, implementers and policy-makers has been shown to improve uptake of health systems research. 5 However, in many places, prioritization and conduct of research is often done solely by academics. 6 Health research is also largely focused on biomedical and clinical interventions, while health systems and implementation research remains underfunded globally. 7 Often, knowledge translation is an add-on activity after the completion of research projects. The World Health Organization’s report, Changing mindsets: strategy on health policy and systems research, called for the embedding of research into health systems processes. 6 This report explained that when embedding happens, researchers and decision-makers are linked through a system in which the need for evidence to inform policy is understood by decision-makers. The Alliance for Health Policy and Systems Research (AHPSR) and the United Nations Children’s Fund (UNICEF) developed a model for implementation research that addresses research priorities identified by decision-makers and specific challenges of local health systems. 8 In this model, policy-makers and implementers at different levels in the health system are engaged as co-investigators and are involved in all phases of a research project. The approach is meant to enhance policy-makers’ and implementers’ ownership of health systems and policy research. The collaboration is designed to prioritize research on empirical questions of local relevance, generate feasible recommendations and integrate evidence into policy-making and health system strengthening. Policy-makers, implementers and researchers are increasingly keen to collaborate on the design and conduct of research to ensure that it contributes to health policy-making. 9 , 10 Since 2013, AHPSR, UNICEF and Gavi, the Vaccine Alliance, have supported 26 embedded research projects in 15 low- and middle-income countries. These projects aim to foster a better understanding of health systems implementation issues linked to maternal, newborn and child health policies and programmes. 11 Through its African Health Initiative, the Doris Duke Charitable Foundation is also supporting embedded research that aims to enhance the performance of health systems in Africa. 12 In these contexts, embedding research in local health systems helped address real concerns of implementers and supports action to alleviate implementation barriers. Our experience is consistent with evidence showing that embedded research facilitates the integration of scientific findings in policy implementation and health systems strengthening. 13 However, few resources are available to support this approach. We advocate for the embedding of locally-relevant and demand-driven research in health systems worldwide to improve the implementation and scale-up of health policies, thus contributing to achievement of the health-related SDGs.
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              Implementation research evidence uptake and use for policy-making

              A major obstacle to the progress of the Millennium Development Goals has been the inability of health systems in many low- and middle-income countries to effectively implement evidence-informed interventions. This article discusses the relationships between implementation research and knowledge translation and identifies the role of implementation research in the design and execution of evidence-informed policy. After a discussion of the benefits and synergies needed to translate implementation research into action, the article discusses how implementation research can be used along the entire continuum of the use of evidence to inform policy. It provides specific examples of the use of implementation research in national level programmes by looking at the scale up of zinc for the treatment of childhood diarrhoea in Bangladesh and the scaling up of malaria treatment in Burkina Faso. A number of tested strategies to support the transfer of implementation research results into policy-making are provided to help meet the standards that are increasingly expected from evidence-informed policy-making practices.
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                Author and article information

                Contributors
                sabin.kiefer@unibas.ch
                astrid.knoblauch@unibas.ch
                peter.steinmann@unibas.ch
                tanja.barth-jaeggi@unibas.ch
                vahedim@who.int
                maherd@who.int
                juerg.utzinger@unibas.ch
                +41 61 284-8140 , kaspar.wyss@unibas.ch
                Journal
                Global Health
                Global Health
                Globalization and Health
                BioMed Central (London )
                1744-8603
                24 March 2017
                24 March 2017
                2017
                : 13
                : 22
                Affiliations
                [1 ]ISNI 0000 0004 0587 0574, GRID grid.416786.a, , Swiss Tropical and Public Health Institute, ; Socinstrasse 57, P.O. Box, CH-4002, Basel, Switzerland
                [2 ]ISNI 0000 0004 1937 0642, GRID grid.6612.3, , University of Basel, ; Basel, Switzerland
                [3 ]GRID grid.463322.2, , The Special Programme for Research and Training in Tropical Diseases, World Health Organization, ; Geneva, Switzerland
                Article
                245
                10.1186/s12992-017-0245-5
                5366106
                28049495
                53ea1fc9-ecff-4faa-b704-2baf72cb4a9a
                © The Author(s). 2017

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 20 February 2017
                : 13 March 2017
                Funding
                Funded by: Special Program for Teaching and Training in Tropical Diseases (TDR).
                Award ID: None
                Award Recipient :
                Categories
                Research
                Custom metadata
                © The Author(s) 2017

                Health & Social care
                implementation research,operational research,global fund,tuberculosis,malaria,research capacity

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