Fulminant Emphysematous Pyelonephritis by Candida glabrata in a Kidney Allograft

Abstract

Emphysematous pyelonephritis (EPN) is a rare and serious necrotizing infection that is potentially life-threatening. It has been seldom reported in kidney grafts and is usually caused by Gram-negative bacteria, with some case reports caused by anaerobic bacteria, and has been closely associated with poorly controlled diabetes mellitus (DM) and urinary tract structural abnormalities. There are no reports of EPN of fungal etiology in kidney grafts. We present a case of a 53-year-old kidney transplant recipient with a history of DM, active vesicoureteral reflux, and recurrent urinary tract infections who developed EPN in the kidney allograft caused by Candida glabrata, 3 weeks after starting treatment with empagliflozin, with an aggressive course that required urgent transplant nephrectomy.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2020

Publication date (Print): June 2020

Publication date (Electronic): 28 April 2020

Volume: 144

Issue: 6

Pages: 304-309

Affiliations

_aNephrology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain

_bInternal Medicine Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain

_cNephrology Department, Hospital Clinico San Carlos, Madrid, Spain

Author notes

*Dr. Amir Shabaka, Servicio de Nefrología, Hospital Universitario Fundación Alcorcón, C/Budapest, 1, ES–28922 Alcorcón, Madrid (Spain), [e-mail]

Article

Publisher ID: 507259 Other ID: Nephron 2020;144:304–309

DOI: 10.1159/000507259

PubMed ID: 32344404

Copyright statement: © 2020 S. Karger AG, Basel

License:

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Page count

Figures: 3, Tables: 3, Pages: 6

Product

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Categories

Subject: Clinical Practice: Case Report