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      MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 2 , 23 , 24 , 16 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 12 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 43 , 17 , 18 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 12 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 26 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 17 , 18 , 12 , 70 , 71 , 72 , 5 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 16 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 2 , 16 , 98 , 99 , 100 , 101 , 33 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 21 , 22 , 158 , 159 , 160 , 161 , 162 , 49 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 128 , 172 , 173 , 174 , 175 , 176 , 177 , 22 , 52 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 23 , 24 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 153 , 212 , 213 , 154 , 214 , 215 , 216 , 217 , 2 , 218 , 219 , 220 , 221 , 222 , 223 , 10 , 224 , 225 , 226 , 227 , 228 , 128 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 29 , 30 , 243 , 244 , 245 , 117 , 246 , 247 , 45 , 46 , 47 , 48 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 195 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 166 , 272 , 273

      Allergy

      Wiley

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          Abstract

          Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards.

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          Most cited references 116

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          • Abstract: found
          • Article: not found

          Rapid changes in flowering time in British plants.

          The average first flowering date of 385 British plant species has advanced by 4.5 days during the past decade compared with the previous four decades: 16% of species flowered significantly earlier in the 1990s than previously, with an average advancement of 15 days in a decade. Ten species (3%) flowered significantly later in the 1990s than previously. These data reveal the strongest biological signal yet of climatic change. Flowering is especially sensitive to the temperature in the previous month, and spring-flowering species are most responsive. However, large interspecific differences in this response will affect both the structure of plant communities and gene flow between species as climate warms. Annuals are more likely to flower early than congeneric perennials, and insect-pollinated species more than wind-pollinated ones.
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            Despite increasing emphasis on the role of clinical decision-support systems (CDSSs) for improving care and reducing costs, evidence to support widespread use is lacking. To evaluate the effect of CDSSs on clinical outcomes, health care processes, workload and efficiency, patient satisfaction, cost, and provider use and implementation. MEDLINE, CINAHL, PsycINFO, and Web of Science through January 2011. Investigators independently screened reports to identify randomized trials published in English of electronic CDSSs that were implemented in clinical settings; used by providers to aid decision making at the point of care; and reported clinical, health care process, workload, relationship-centered, economic, or provider use outcomes. Investigators extracted data about study design, participant characteristics, interventions, outcomes, and quality. 148 randomized, controlled trials were included. A total of 128 (86%) assessed health care process measures, 29 (20%) assessed clinical outcomes, and 22 (15%) measured costs. Both commercially and locally developed CDSSs improved health care process measures related to performing preventive services (n= 25; odds ratio [OR], 1.42 [95% CI, 1.27 to 1.58]), ordering clinical studies (n= 20; OR, 1.72 [CI, 1.47 to 2.00]), and prescribing therapies (n= 46; OR, 1.57 [CI, 1.35 to 1.82]). Few studies measured potential unintended consequences or adverse effects. Studies were heterogeneous in interventions, populations, settings, and outcomes. Publication bias and selective reporting cannot be excluded. Both commercially and locally developed CDSSs are effective at improving health care process measures across diverse settings, but evidence for clinical, economic, workload, and efficiency outcomes remains sparse. This review expands knowledge in the field by demonstrating the benefits of CDSSs outside of experienced academic centers. Agency for Healthcare Research and Quality.
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              Allergenic pollen and pollen allergy in Europe.

              The allergenic content of the atmosphere varies according to climate, geography and vegetation. Data on the presence and prevalence of allergenic airborne pollens, obtained from both aerobiological studies and allergological investigations, make it possible to design pollen calendars with the approximate flowering period of the plants in the sampling area. In this way, even though pollen production and dispersal from year to year depend on the patterns of preseason weather and on the conditions prevailing at the time of anthesis, it is usually possible to forecast the chances of encountering high atmospheric allergenic pollen concentrations in different areas. Aerobiological and allergological studies show that the pollen map of Europe is changing also as a result of cultural factors (for example, importation of plants such as birch and cypress for urban parklands), greater international travel (e.g. colonization by ragweed in France, northern Italy, Austria, Hungary etc.) and climate change. In this regard, the higher frequency of weather extremes, like thunderstorms, and increasing episodes of long range transport of allergenic pollen represent new challenges for researchers. Furthermore, in the last few years, experimental data on pollen and subpollen-particles structure, the pathogenetic role of pollen and the interaction between pollen and air pollutants, gave new insights into the mechanisms of respiratory allergic diseases.
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                Author and article information

                Journal
                Allergy
                Allergy
                Wiley
                01054538
                November 2015
                November 2015
                September 13 2015
                : 70
                : 11
                : 1372-1392
                Affiliations
                [1 ]University Hospital; Montpellier France
                [2 ]MACVIA-LR; Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc - Roussillon; European Innovation Partnership on Active and Healthy Ageing Reference Site; Montpellier France
                [3 ]INSERM; VIMA: Ageing and Chronic Diseases; Epidemiological and Public Health Approaches; Paris France
                [4 ]UVSQ; UMR-S 1168; Université Versailles St-Quentin-en-Yvelines; Paris France
                [5 ]Department of Clinical Epidemiology and Biostatistics and Medicine; McMaster University; Hamilton ON Canada
                [6 ]Center for Research in Health Technologies and Information Systems - CINTESIS; Universidade do Porto; Porto Portugal
                [7 ]Allergy Unit; Instituto CUF Porto e Hospital CUF Porto; Porto Portugal
                [8 ]Health Information and Decision Sciences Department - CIDES; Faculdade de Medicina; Universidade do Porto; Porto Portugal
                [9 ]Faculdade de Medicina da Universidade do Porto; Porto Portugal
                [10 ]Department of Prevention of Environmental Hazards and Allergology; Medical University of Warsaw; Warsaw Poland
                [11 ]Upper Airways Research Laboratory; ENT Department; Ghent University Hospital; Ghent Belgium
                [12 ]Allergy and Respiratory Diseases Clinic; DIMI; University of Genoa; IRCCS AOU San Martino-IST; Genoa Italy
                [13 ]Division of Allergy/Immunology; University of South Florida; Tampa FL USA
                [14 ]ProAR - Nucleo de Excelencia em Asma; Federal University of Bahia; Bahia Brasil
                [15 ]GARD Executive Committee; Bahia Brasil
                [16 ]Department of Respiratory Diseases; Montpellier University Hospital; Montpellier France
                [17 ]EPAR U707 INSERM; Paris France
                [18 ]EPAR UMR-S UPMC; Paris France
                [19 ]Laboratory of Clinical Immunology; Department of Microbiology and Immunology; KU Leuven; Leuven Belgium
                [20 ]Vilnius University Clinic of Children's Diseases; Vilnius Lithuania
                [21 ]Sachs’ Children's Hospital; Stockholm Sweden
                [22 ]Institute of Environmental Medicine; Karolinska Institutet; Stockholm Sweden
                [23 ]Department of Dermatology and Allergy; Charité - Universitätsmedizin Berlin; Berlin Germany
                [24 ]Member of the Global Allergy and Asthma European Network (GA2LEN); Oslo Norway
                [25 ]Woolcock Institute of Medical Research; University of Sydney and Sydney Local Health District; Glebe NSW Australia
                [26 ]Department of Dermatology and Allergy Centre; Odense University Hospital; Odense Denmark
                [27 ]Department of Otorhinolaryngology; Academic Medical Centre; Amsterdam The Netherlands
                [28 ]Latvian Association of Allergists; Center of Tuberculosis and Lung Diseases of Latvia; Riga Latvia
                [29 ]Department of Paediatrics; Oslo University Hospital; Oslo Norway
                [30 ]Faculty of Medicine; Institute of Clinical Medicine; University of Oslo; Oslo Norway
                [31 ]Unitat de Rinologia i Clínica de l'Olfacte; Servei d'ORL; Hospital Clínic; Clinical & Experimental Respiratory Immunoallergy; IDIBAPS; Barcelona Catalonia Spain
                [32 ]Food Allergy Referral Centre Veneto Region; Department of Women and Child Health; Padua General University Hospital; Padua Italy
                [33 ]EFA European Federation of Allergy and Airways Diseases Patients’ Associations; Brussels Belgium
                [34 ]Center for Pediatrics and Child Health; Institute of Human Development; Royal Manchester Children's Hospital; University of Manchester; Manchester UK
                [35 ]Allergy Department; 2nd Pediatric Clinic; Athens General Children's Hospital “P&A Kyriakou”; University of Athens; Athens Greece
                [36 ]General Practitioner; Woodbrook Medical Centre; Loughborough UK
                [37 ]Honorary Clinical Research Fellow; Allergy and Respiratory Research Group; The University of Edinburgh; Edinburgh UK
                [38 ]Department of Lung Diseases and Clinical Allergology; University of Turku; Turku Finland
                [39 ]Department of Pulmonology; Celal Bayar University; Manisa Turkey
                [40 ]Department of Dermatology; Medical University of Graz; Graz Austria
                [41 ]Transylvania University Brasov; Brasov Romania
                [42 ]Department of Clinical Research Center; International University of Health and Welfare/Sanno Hospital; Tokyo Japan
                [43 ]Swiss Institute of Allergy and Asthma Research (SIAF); University of Zurich; Davos Switzerland
                [44 ]Department of Allergy and Immunology; Hospital Quirón Bizkaia; Erandio Spain
                [45 ]Centre for Research in Environmental Epidemiology; Barcelona Spain
                [46 ]Hospital del Mar Research Institute; Barcelona Spain
                [47 ]CIBER Epidemiología y Salud Pública; Barcelona Spain
                [48 ]Department of Experimental and Health Sciences; University of Pompeu Fabra; Barcelona Spain
                [49 ]Digi Health; Montpellier France
                [50 ]David Hide Asthma and Allergy Research Centre; Isle of Wight UK
                [51 ]EuroAsian Respiratory Society; Astana City Kazakhstan
                [52 ]Faculdade de Medicina de Lisboa; Portuguese National Programme for Respiratory Diseases; Lisbon Portugal
                [53 ]Department of Medicine; University of Cape Town; Cape Town South Africa
                [54 ]Section of Respiratory Disease; Department of Oncology, Haematology and Respiratory Diseases; University of Modena and Reggio Emilia; Modena Italy
                [55 ]Department of Respiratory Medicine; Academic Medical Center; University of Amsterdam; Amsterdam The Netherlands
                [56 ]Service de Pneumologie IV; Hôpital Abderrahman Mami; Ariana Tunisie
                [57 ]Department of Respiratory Medicine; National Institute of Diseases of the Chest and Hospital; Dhaka Bangladesh
                [58 ]Centre for Individualized Medicine; Department of Pediatrics; Faculty of Medicine; Linköping University; Linköping Sweden
                [59 ]Deputy National Medical Director; NHS England; England UK
                [60 ]Department of Dermatology and Allergy; Rheinische Friedrich-Wilhelms-University Bonn; Bonn Germany
                [61 ]Department of Respiratory Medicine and Allergology; University Hospital; Lund Sweden
                [62 ]Department of Geriatrics; Montpellier University Hospital; Montpellier France
                [63 ]EA 2991 Movement To Health; Euromov; University Montpellier; Montpellier France
                [64 ]Pediatric Department; University of Verona Hospital; Verona Italy
                [65 ]Québec Heart and Lung Institute; Laval University; Québec City QC Canada
                [66 ]Department of Public Health and Infectious Diseases; Sapienza University of Rome; Rome Italy
                [67 ]Second University of Naples and Institute of Translational Medicine; Italian National Research Council; Naples Italy
                [68 ]Allergist; La Rochelle France
                [69 ]Directeur Général Adjoint; Montpellier University Hospital; Montpellier France
                [70 ]Health Economics and Health Technology Assessment; Institute of Health & Wellbeing; University of Glasgow; Glasgow UK
                [71 ]Institute of Lung Health; Respiratory Biomedical Unit; University Hospitals of Leicester NHS Trust; Leicestershire UK
                [72 ]Department of Infection, Immunity and Inflammation; University of Leicester; Leicester UK
                [73 ]Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Mainz Germany
                [74 ]National Heart and Lung Institute; Imperial College; London UK
                [75 ]Wellcome Centre for Global Health; Imperial College; London UK
                [76 ]MRC-PHE Centre for Environment and Health; Imperial College; London UK
                [77 ]Imperial College and Royal Brompton Hospital; London UK
                [78 ]Centro Medico Docente La Trinidad; CaRacas Venezuela
                [79 ]Imperial College London - National Heart and Lung Institute; Royal Brompton Hospital NHS; London UK
                [80 ]Federal University of Minas Gerais; Medical School; Department of Pediatrics; Belo Horizonte Brazil
                [81 ]Assitant Director General; Montpellier France
                [82 ]Région Languedoc Roussillon; Roussillon France
                [83 ]Department of Paediatrics; Oslo University Hospital and University of Oslo; Oslo Norway
                [84 ]Allergy and Asthma Associates of Southern California; Mission Viejo CA USA
                [85 ]Allergy and Immunology Laboratory; Metropolitan University; Simon Bolivar University; Barranquilla Colombia
                [86 ]SLaai; Sociedad Latinoamericana de Allergia; Asma e Immunologia; Barranquilla Colombia
                [87 ]Department of Public Health and Primary Care; Leiden University Medical Center; Leiden The Netherlands
                [88 ]Department of Social Medicine; Faculty of Medicine; University of Crete; Heraklion Crete Greece
                [89 ]National Cooperative Group of Paediatric Research on Asthma; Asthma Clinic and Education Center of the Capital Institute of Pediatrics; Peking and Center for Asthma Research and Education; Beijing China
                [90 ]Chachava Clinic; David Tvildiani Medical University-AIETI Medical School; Grigol Robakidze University; Tbilisi Georgia
                [91 ]Pulmonolory Research Institute FMBA; Moscow Russia
                [92 ]GARD Executive Committee; Moscow Russia
                [93 ]Medicine Department; IRCCS-Azienda Ospedaliera Universitaria San Martino; Genoa Italy
                [94 ]Latvian Association of Allergists; University Children Hospital of Latvia; Riga Latvia
                [95 ]Life and Health Sciences Research Institute; ICVS; School of Health Sciences; University of Minho; Braga Portugal
                [96 ]Department of Medicine; Nova Southeastern University; Davie FL USA
                [97 ]European Innovation Partnership on Active and Healthy Ageing; Reference Site; NHS Scotland; Glasgow UK
                [98 ]Centre for Respiratory Medicine and Allergy; Institute of Inflammation and Repair; University of Manchester and University Hospital of South Manchester; Manchester UK
                [99 ]The Centre for Allergy Research; The Institute of Environmental Medicine; Karolinska Institutet; Stockholm Sweden
                [100 ]Department of Dermatology and Allergy; Technische Universität Mänchen; Munich Germany
                [101 ]ZAUM-Center for Allergy and Environment; Helmholtz Center Munich; Technische Universität München; Munich Germany
                [102 ]Allergy Division; Chest Disease Department; University Hospital of Strasbourg; Strasbourg France
                [103 ]European Regional and Local Health Association; Brussels Belgium
                [104 ]Allergology and Immunology Discipline; “Iuliu Hatieganu” University of Medicine and Pharmacy; Cluj-Napoca Romania
                [105 ]Department of Medicine; Division of Clinical Immunology and Allergy; McMaster University; Hamilton ON Canada
                [106 ]Laboratoire de Pharmacologie Respiratoire UPRES EA220; Hôpital Foch; Suresnes Université Versailles Saint-Quentin; Versailles Saint-Quentin France
                [107 ]Respiratory Diseases Department; Rangueil-Larrey Hospital; Toulouse France
                [108 ]Service de physiologie; Hôpital Cochin; Université Paris-Descartes; Assistance publique-Hôpitaux de Paris; Paris France
                [109 ]Medical Faculty Skopje; University Clinic of Pulmology and Allergy; Skopje R. Macedonia
                [110 ]Service de Pneumo-Allergologie; Centre Hospitalo-Universitaire de Béni-Messous; Algers Algeria
                [111 ]Ecole des Mines; Alès France
                [112 ]Medical Faculty; Vilnius University; Vilnius Lithuania
                [113 ]Allergy and Clinical Immunology Section; National Heart and Lung Institute; Imperial College London; London UK
                [114 ]Section of Allergy and Immunology; Saint Louis University School of Medicine; Saint Louis MI USA
                [115 ]Pediatric Allergy and Immunology Unit; Ain Shams University; Cairo Egypt
                [116 ]Clinic of Children's Diseases; Faculty of Medicine; Vilnius University; Vilnius Lithuania
                [117 ]Global Allergy and Asthma Platform GAAPP; Vienna Austria
                [118 ]Education for Health; Warwick UK
                [119 ]Allergy Department; The Bambino Gesù Children's Research Hospital Holy see; Rome Italy
                [120 ]Department of Epidemiology; Regional Health Service Lazio Region; Rome Italy
                [121 ]National Center for Disease Control and Public Health of Georgia; Tbilisi Georgia
                [122 ]Turkish Thoracic Society Asthma-Allergy Working Group; Kocaeli Turkey
                [123 ]Allergy and Immunology Division; Clinica Ricardo Palma; Lima Peru
                [124 ]Sociedad Latinoamericana de Allergia; Asma e Immunologia; Mexico City Mexico
                [125 ]Center of Allergy and Immunology; Georgian Association of Allergology and Clinical Immunology; Tbilisi Georgia
                [126 ]Faculty of the Department of Neurology; University of Washington School of Medicine; Seattle WA USA
                [127 ]Immunology and Allergy Division; Clinical Hospital; University of Chile; Santiago Chile
                [128 ]Skin and Allergy Hospital; Helsinki University Hospital; Helsinki Finland
                [129 ]Department of Respiratory Diseases; Odense University Hospital; Odense Denmark
                [130 ]Institute of Epidemiology I; German Research Centre for Environmental Health; Helmholtz Zentrum München; Neuherberg Germany
                [131 ]Vienna Challenge Chamber; Vienna Austria
                [132 ]Department of Paediatrics and Child Health; University College Cork; Cork Ireland
                [133 ]University of Southampton Faculty of Medicine; University Hospital Southampton; Southampton UK
                [134 ]Université Paris-Sud; Le Kremlin Bicêtre France
                [135 ]Service de Pneumologie; Hôpital Bicêtre; Inserm UMR_S999; Le Kremlin Bicêtre France
                [136 ]School of Psychology; Plymouth University; Plymouth UK
                [137 ]Servicio de Alergia e Immunologia; Clinica Santa Isabel; Buenos Aires Argentina
                [138 ]Libra Foundation; Buenos Aires Argentina
                [139 ]Airway Disease Infection Section; National Heart and Lung Institute; Imperial College; London UK
                [140 ]MRC & Asthma UK Centre in Allergic Mechanisms of Asthma; London UK
                [141 ]Department of Respiratory Medicine; Ghent University Hospital; Ghent Belgium
                [142 ]Medical Commission; Montpellier University Hospital; Montpellier France
                [143 ]Hallym University College of Medicine; Hallym University Sacred Heart Hospital; Gyeonggi-do South Korea
                [144 ]Allergology Department; Centre de l'Asthme et des Allergies. Hôpital d'Enfants Armand-Trousseau; Paris France
                [145 ]Sorbonne Universités; UPMC Univ Paris 06; UMR_S 1136; Institut Pierre Louis d'Epidémiologie et de Santé Publique; Equipe EPAR; Paris France
                [146 ]Ukrainian Medical Stomatological Academy; Poltava Ukraine
                [147 ]Pediatric Allergy and Asthma Unit; Hacettepe University School of Medicine; Ankara Turkey
                [148 ]School of Medicine; Department of Chest Diseases, Immunology and Allergy Division; Hacettepe University; Ankara Turkey
                [149 ]Institute of Social Medicine, Epidemiology and Health Economics; Charité - Universitätsmedizin Berlin; Berlin Germany
                [150 ]Institute for Clinical Epidemiology and Biometry; University of Wuerzburg; Wuerzburg Germany
                [151 ]Department of Medicine; McMaster University; Health Sciences Centre 3V47; Hamilton ON Canada
                [152 ]GARD Chairman; Geneva Switzerland
                [153 ]Center for Rhinology and Allergology; Wiesbaden Germany
                [154 ]Société de Pneumologie de Langue Française et Espace Francophone de Pneumologie; Paris France
                [155 ]Department of Respiratory Medicine; Faculty of Medicine and Dentistry; University Hospital Olomouc; Olomouc Czech Republic
                [156 ]Department of Pediatric Pulmonology and Pediatric Allergology; Beatrix Children's Hospital; GRIAC Research Institute; University of Groningen; University Medical Center Groningen; Groningen The Netherlands
                [157 ]Department of Immunology, Rheumatology and Allergy; Medical University of Lodz; Lodz Poland
                [158 ]Division of Internal Medicine, Asthma and Allergy; KUNA; Barlicki University Hospital; Medical University of Lodz; Lodz Poland
                [159 ]Pulmonology and Allergology Center; Vilnius University; Vilnius Lithuania
                [160 ]VIB Inflammation Research Center; Ghent University; Ghent Belgium
                [161 ]Department for Pediatric Pneumology and Immunology; Charité Medical University; Berlin Germany
                [162 ]Clínica de Alergia; Asma y Pediatría; Hospital Médica Sur; México City México
                [163 ]University of Medicine and Pharmacy; Hochiminh City Vietnam
                [164 ]Departments of Internal Medicine and Pediatrics (Divisions of Allergy and Immunology); University of Tennessee College of Medicine; Germantown TN USA
                [165 ]Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine; Medical Research Institute; Ninewells Hospital; University of Dundee; Dundee UK
                [166 ]State Key Laboratory of Respiratory Diseases; Guangzhou Institute of Respiratory Disease; the First Affiliated Hospital of Guangzhou Medical University; Guangzhou China
                [167 ]Department of Pulmonary Medicine; CHU Sart-Tilman; Liege Belgium
                [168 ]Service de Pneumo-allergologie; Hôpital Saint-Joseph; Paris France
                [169 ]Service de Pneumologie; University of Nantes; UMR INSERM; UMR1087/CNR 6291; l'Institut du Thorax; Nantes France
                [170 ]Department of Pulmonary Medicine; Rashid Hospital; Dubai UAE
                [171 ]Department of Respiratory Medicine; University Hospital; Bratislava Slovakia
                [172 ]Department of Medicine (RCSI); Bon Secours Hospital; Glasnevin Dublin Ireland
                [173 ]Kronikgune; Basque Region Spain
                [174 ]Division of Clinical Immunology and Allergy; Laboratory of Behavioral Immunology Research; The University of Mississippi Medical Center; Jackson MS USA
                [175 ]Respiratory Disease Research; Shahid Beheshti University of Medical Sciences; Tehran Iran
                [176 ]Allergie-Centrum-Charité at the Department of Dermatology and Allergy; Charité - Universitätsmedizin Berlin; Berlin Germany
                [177 ]Department of Paediatrics; Maputo Central Hospital; Maputo Mozambique
                [178 ]Allergy and Asthma Medical Group and Research Center; San Diego CA USA
                [179 ]Hautklinik - Klinik für Dermatologie & Allergologie; Universitätsklinikum der RWTH Aachen; Aachen Deutschland
                [180 ]Croatian Pulmonary Society; Zagreb Croatia
                [181 ]National Institute of Pneumology M. Nasta; Bucharest Romania
                [182 ]Faculty of Medicine; University of Belgrade; Belgrade Serbia
                [183 ]Serbian Association for Asthma and COPD; Belgrade Serbia
                [184 ]National Center for Research in Chronic Respiratory Diseases; Tishreen University School of Medicine; Latakia Syria
                [185 ]Département de Pharmacologie; CHU de Bordeaux; Université Bordeaux; INSERM U657; Bordeaux Cedex France
                [186 ]Department of Public Health and Biostatistics; Paris Descartes University; Paris France
                [187 ]Paris Municipal Department of Social Action; Childhood and Health; Paris France
                [188 ]Aura Andalucia; Jaen Spain
                [189 ]Allergy and Clinical Immunology Department; Hospital CUF-Descobertas; Lisboa Portugal
                [190 ]Institute of Medical Statistics, Informatics and Epidemiology; Medical Faculty; University of Cologne; Cologne Germany
                [191 ]Scientific Centre of Children's Health under the Russian Academy of Medical Sciences; Moscow Russia
                [192 ]Section of Otolaryngology-Head and Neck Surgery; The University of Chicago Medical Center and The Pritzker School of Medicine; The University of Chicago; Chicago IL USA
                [193 ]Hospital de Niños Orlando Alassia; Santa Fe Argentina
                [194 ]Hospital of the Hospitaller Brothers in Buda; Budapest Hungary
                [195 ]Pediatric Pneumology and Immunology; Charité Universitätsmedizin Berlin; Berlin Germany
                [196 ]ENT Department; University Hospital of Kinshasa; Kinshasa Congo
                [197 ]Department of Allergy, Immunology and Respiratory Medicine; Alfred Hospital and Central Clinical School; Monash University; Melbourne Vic. Australia
                [198 ]Department of Immunology; Monash University; Melbourne Vic. Australia
                [199 ]National Hospital Organization; Tokyo National Hospital; Tokyo Japan
                [200 ]Depatment of Otorhinolaryngology; Chiba University Hospital; Chiba Japan
                [201 ]Depatment of Otolaryngology; Nippon Medical School; Tokyo Japan
                [202 ]Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle; Ouagadougou Burkina Faso
                [203 ]Cardio-Thoracic and Vascular Department; University Hospital of Pisa; Pisa Italy
                [204 ]Dept. of Comparative Medicine; Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University and University Vienna; Vienna Austria
                [205 ]Messerli Research Institute of the University of Veterinary Medicine Vienna; Medical University and University Vienna; Vienna Austria
                [206 ]Centre for Health Economics; University of York; York, UK
                [207 ]Department of Immunology and Allergology; Faculty of Medicine and Faculty Hospital in Pilsen; Charles University in Prague; Pilsen Czech Republic
                [208 ]Respiratory Medicine; Department of Medical Sciences; University of Ferrara; Ferrara Italy
                [209 ]Department of Allergy and Clinical Immunology; Ajou University School of Medicine; Suwon South Korea
                [210 ]Nuffield Department of Medicine; University of Oxford; Oxford UK
                [211 ]Department of Pediatrics; Nippon Medical School; Tokyo Japan
                [212 ]Department of Otorhinolaryngology, Head and Neck Surgery; Medical Faculty Mannheim; Universitätsmedizin Mannheim; Heidelberg University; Mannheim Germany
                [213 ]Conseil Général de l'Economie. Ministère de l'Economie; de l'Industrie et du Numérique; Paris France
                [214 ]Département de pédiatrie; CHU de Grenoble; Grenoble cedex 9 France
                [215 ]Children's Hospital Srebrnjak; Zagreb; School of Medicine; University J.J. Strossmayer; Osijek Croatia
                [216 ]Karl Landsteiner Institute for Clinical and Experimental Pneumology; Hietzing Hospital; Vienna Austria
                [217 ]Clinic of Allergy & Asthma; Medical University Sofia; Sofia Bulgaria
                [218 ]Department of Pulmonary Medicine and Tuberculosis; GRIAC Research Institute; University of Groningen; University Medical Center Groningen; Groningen The Netherlands
                [219 ]Allergy Diagnostic and Clinical Research Unit; University of Cape Town Lung Institute; Cape Town South Africa
                [220 ]Academic Centre of Primary Care; University of Aberdeen; Aberdeen UK
                [221 ]Research in Real-Life; Cambridge UK
                [222 ]LungenClinic Grosshansdorf; Airway Research Center North; Member of the German Center for Lung Research; Grosshansdorf Germany
                [223 ]Department of Medicine; Christian Albrechts University; Airway Research Center North; Member of the German Center for Lung Research; Kiel Germany
                [224 ]Conseil Départemental de l'Ordre des Pharmaciens; Maison des Professions Libérales; Montpellier France
                [225 ]SLAAI; Mexico City, Mexico
                [226 ]Allergy and Clinical Immunology Department; Hospitais da Universidade de Coimbra; Coimbra Portugal
                [227 ]Association Asthme et Allergie; Paris France
                [228 ]Serviço de Imunoalergologia; Hospital da Luz; Lisboa Portugal
                [229 ]Polibienestar Research Institute; University of Valencia; Valencia Spain
                [230 ]Primary Care Respiratory Research Unit; Institutode Investigación Sanitaria de Palma IdisPa; Palma de Mallorca Spain
                [231 ]Allergy Unit; Complesso Integrato Columbus; Rome Italy
                [232 ]Hospital de Clinicas; University of Parana; Parana Brazil
                [233 ]Department of Allergy, Asthma and Immunology; Children's Mercy Hospitals and Clinics and Pediatrics and Medicine University of Misouri-Kansas City School of Medicine; Kansas City MI USA
                [234 ]Division of Allergy Asthma and Clinical Immunology; Emek Medical Center; Afula Israel
                [235 ]Allergy and Clinical Immunology Department; Centro Médico-Docente la; Trinidad Venezuela
                [236 ]Clínica El Avila; 6a transversal Urb; Caracas Venezuela
                [237 ]The Royal National TNE Hospital; University College London; London UK
                [238 ]Otolaryngology and Head & Neck Surgery; CHU Rangueil-Larrey; Toulouse France
                [239 ]Allergy Unit; Department of Dermatology; University Hospital of Zurich; Zürich Switzerland
                [240 ]Allergy and Respiratory Research Group; Medical School; Centre for Population Health Sciences; The University of Edinburgh; Edinburgh UK
                [241 ]Department of Pediatrics & Child Health; Department of Immunology; Faculty of Medicine; University of Manitoba; Winnipeg MB Canada
                [242 ]Sociedad Paraguaya de Alergia Asma e Inmunologıa; Paraguay Paraguay
                [243 ]Julius Center of Health Sciences and Primary Care; University Medical Center Utrecht; University of Utrecht; Utrecht The Netherlands
                [244 ]Division of Allergy, Clinical Immunology and Rheumatology; Department of Pediatrics; Federal University of São Paulo; São Paulo Brazil
                [245 ]Kyrgyzstan National Centre of Cardiology and Internal medicine; Euro-Asian respiratory Society; Bishkek Kyrgyzstan
                [246 ]Pulmonary Division; Heart Institute (InCor); Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo; Sao Paulo Brazil
                [247 ]European Union GeriatricMedicine Society; Vienna Austria
                [248 ]Department of Epidemiology; CAPHRI School of Public Health and Primary Care; Maastricht University; Maastricht The Netherlands
                [249 ]Centre of Pneumology; Faculty of Medicine; University of Coimbra; Coimbra Portugal
                [250 ]Division of Allergy and Clinical Immunology; University of Salerno; Salerno Italy
                [251 ]Division of Immunopathology; Department of Pathophysiology and Allergy Research; Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna; Vienna Austria
                [252 ]Pneumology and Allergy Department; Hospital Clínic; Clinical & Experimental Respiratory Immunoallergy; IDIBAPS; Barcelona Spain
                [253 ]Clinical Immunology and Allergy Unit; Department of Medicine Solna; Karolinska Institutet and University Hospital; Stockholm Sweden
                [254 ]Department of Chest Medicine; Centre Hospitalier Universitaire Dinant-Godinne; Université Catholique de Louvain; Yvoir Belgium
                [255 ]Pulmonary Unit; Department of Cardiology, Thoracic and Vascular Medicine; Arcispedale S.Maria Nuova/IRCCS; Research Hospital; Reggio Emilia Italy
                [256 ]Regional Agency for Health and Social Care; Reggio Emilia Italy
                [257 ]Division of Allergy and Immunology; Department of Pediatrics; Siriraj Hospital; Mahidol University Faculty of Medicine; Bangkok Thailand
                [258 ]Pulmonary Environmental Epidemiology Unit; CNR Institute of Clinical Physiology; Pisa Italy
                [259 ]CNR Institute of Biomedicine and Molecular Immunology “A. Monroy”; Palermo Italy
                [260 ]Department of Otorhinolaryngology; HNO-Klinik; Universitätsklinikum Düsseldorf; Düsseldorf Germany
                [261 ]Asthma UK; London UK
                [262 ]Department of Otolaryngology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore City Singapore
                [263 ]Eshelman School of Pharmacy; University of North Carolina; Chapel Hill NC USA
                [264 ]Bradford Institute for Health Research; Bradford Royal Infirmary; Bradford UJ USA
                [265 ]Department of Research; Olmsted Medical Center; Rochester MN USA
                [266 ]Cyprus International Institute for Environmental & Public Health in Association with Harvard School of Public Health; Cyprus University of Technology; Limassol Cyprus
                [267 ]Department of Pediatrics; Hospital “Archbishop Makarios III”; Nicosia Cyprus
                [268 ]The Allergy and Asthma Institute; Islamabad Pakistan
                [269 ]Department of Paediatrics and Child Health; Red Cross Children's Hospital; MRC Unit on Child & Adolescent Health; University of Cape Town; Cape Town South Africa
                [270 ]Universidad Católica de Córdoba; Córdoba Argentina
                [271 ]Department of Otolaryngology, Head and Neck Surgery; Beijing Tongren Hospital; Capital Medical University; Beijing China
                [272 ]University Clinic of Respiratory and Allergic Diseases; Golnik Slovenia
                [273 ]Vice President for Research; University Montpellier; Montpellier France
                Article
                10.1111/all.12686
                26148220
                © 2015
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                Self URI (article page): http://doi.wiley.com/10.1111/all.12686

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