Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

Influencia de los esteroides sexuales sobre el índice de resistencia a la insulina HOMAIR y presión arterial durante el ciclo menstrual

Read this article at

Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Objetivo: Evaluar los esteroides sexuales, insulinemia y HOMAIR durante el ciclo menstrual y su relación con la presión arterial y variables antropométricas. Métodos: La presión arterial y la frecuencia cardíaca fueron medidas durante las fases folicular y luteal en 17 mujeres con ciclos menstruales regulares. Los índices de masa corporal y cintura: cadera fueron calculados. La concentración plasmática de insulina, estradiol y progesterona se cuantificó en ambas fases del ciclo menstrual. Se calculó el índice de resistencia a la insulina HOMAIR. Ambiente: Consulta de la Unidad de Endocrinología del Hospital Universitario de Los Andes, Mérida, Venezuela. Resultados: La presión arterial y la frecuencia cardíaca no se modificaron durante el ciclo menstrual ni se correlacionaron con los niveles séricos de estradiol, progesterona e insulinemia. No se observó variación circadiana de la presión arterial. El índice cintura: cadera se correlacionó positivamente con la presión arterial sistólica en la fase folicular. Conclusiones: En condiciones de reposo, la presión arterial y frecuencia cardíaca no se modifican durante el ciclo menstrual. La adiposidad y la distribución regional de la grasa podrían modular la presión arterial en edades tempranas de la vida.

      Translated abstract

      Objective: To evaluate sex steroids and fasting insulin during menstrual cycle and its relationship with blood pressure and anthropometric variables. Method: Blood pressure and heart rate were measured in the morning and afternoon during follicular and luteal phase in 17 women with normal menstrual cycles. Body mass index and waist:hip ratio were calculated. Plasma levels of fasting insulina, estradiol and progesterone were measured in both phases of menstrual cycle. The insulin resistance index HOMAIR was calculated. Setting: Endocrinology Unit at Los Andes University Hospital, Merida, Venezuela Results: Blood pressure and heart rate did not change during menstrual cycle. No correlation was found between blood pressure, sex steroids and insulinemia. Circadian changes were not observed in blood pressure. Waist: hip ratio was positively correlated with systolic blood pressure during follicular phase. Conclusions: In resting conditions, blood pressure and heart rate do not modify during menstrual cycle. Adiposity and regional fat distribution might modulate blood pressure during early life.

      Related collections

      Most cited references 46

      • Record: found
      • Abstract: not found
      • Article: not found

      The protective effects of estrogen on the cardiovascular system.

        Bookmark
        • Record: found
        • Abstract: not found
        • Article: not found

        Physiological action of progesterone in target tissues.

          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          Insulin resistance and hypertension.

           James Sowers (2004)
          Diminished insulin (Ins) sensitivity is a characteristic feature of various pathological conditions such as the cardiometabolic syndrome, Type 2 diabetes, and hypertension. Persons with essential hypertension are more prone than normotensive persons to develop diabetes, and this propensity may reflect decreased ability of Ins to promote relaxation and glucose transport in vascular and skeletal muscle tissue, respectively. There are increasing data suggesting that ANG II acting through its ANG type 1 receptor inhibits the actions of Ins in vascular and skeletal muscle tissue, in part, by interfering with Ins signally through phosphatidylinositol 3-kinase (PI3K) and its downstream protein kinase B (Akt) signaling pathways. This inhibitory action of ANG II is mediated, in part, through stimulation of RhoA activity and oxidative stress. Activated RhoA and increased reactive oxygen species inhibition of PI3K/Akt signaling results in decreased endothelial cell production of nitric oxide, increased myosin light chain activation with vasoconstriction, and reduced skeletal muscle glucose transport.
            Bookmark

            Author and article information

            Affiliations
            [1 ] Universidad de Los Andes Venezuela
            Contributors
            Role: ND
            Role: ND
            Journal
            og
            Revista de Obstetricia y Ginecología de Venezuela
            Rev Obstet Ginecol Venez
            Sociedad de Obstetricia y Ginecología de Venezuela (Caracas )
            0048-7732
            March 2005
            : 65
            : 1
            : 15-18
            S0048-77322005000100003

            http://creativecommons.org/licenses/by/4.0/

            Product
            Product Information: SciELO Venezuela
            Categories
            OBSTETRICS & GYNECOLOGY

            Comments

            Comment on this article