Second Messenger Changes of Atrial Natriuretic Factor and Brain Natriuretic Peptide in Kidneys of Cardiomyopathic Hamsters

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Abstract

The effects of natriuretic peptides in kidney are blunted in congestive heart failure (CHF). The aim of this study is to examine the changes of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) second messenger productions in CHF. Experiments were conducted on 300-day-old normal and cardiomyopathic hamsters. Blood was collected for ANF measurement. cGMP accumulation studies were done in glomeruli upon ANF and BNP stimulation, and in inner medullary collecting duct (IMCD) cells upon ANF stimulation. Higher plasma ANF levels were found in cardiomyopathic hamsters (811.3 ± 124.6 vs. 166.6 ± 13pg/ml, p < 0.01). ANF-stimulated cGMP accumulations in glomeruli and IMCD cells were higher in cardiomyopathic hamsters. Increased BNP-stimulated cGMP accumulations were also observed in cardiomyopathic hamster glomeruli. These results suggest that the renal hyporesponsiveness to natriuretic peptides in CHF is not due to attenuated ANF and BNP second messenger productions.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 18 November 2008

Volume: 85

Issue: 2

Pages: 82-87

Affiliations

Department of Medicine, University of British Columbia, University Hospital, Vancouver, Canada

Article

Publisher ID: 176652 Other ID: Cardiology 1994;85:82–87

DOI: 10.1159/000176652

PubMed ID: 7954567

SO-VID: 54221da3-bae3-42e8-90fb-47668b51d53b

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History

Date received : 21 June 1993

Date accepted : 18 February 1994

Page count

Pages: 6

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