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      Aerobic exercise and insulin resistance indicators in sedentary women

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          Abstract

          Abstract The aim of this study is to determine the concordance between the insulin resistance indicators, HOMA and TyG, because of a moderate intensity aerobic exercise session in sedentary young women. Methods. A total of 22 sedentary women between 18 and 35 years of age participated in this research. HOMA and TyG indices were determined before and after a moderate intensity aerobic exercise (MIAE), based on Heart Rate reserve. Spearman and Kendall's Tau-b were used to evaluate the association between those variables. Values were compared using the Bland & Altman graphs. Kappa Coefficient was used to estimate the proportion of concordance observed between both indicators. Significant differences were considered at a p≤0.01. Results. Spearman's Rho correlation and Kendall's Tau-b before MIAE were significant and direct (r=0.634, p<0.001 and r=0.480, p<0.01; respectively) with a Cohen's Kappa index of k=0.585. After MIAE, Spearman's Rho correlation and Kendall's Tau-b were also significant and direct r=0.650, p<0.001 and r=0.504, p<0.001, respectively, with a lower Cohen's Kappa index (k=0.390). Conclusions. TyG index is a good indicator to evaluate insulin resistance at baseline situations. However, this index doesn't properly determine insulin resistance after a MIAE.

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          Compendium of Physical Activities: an update of activity codes and MET intensities

          We provide an updated version of the Compendium of Physical Activities, a coding scheme that classifies specific physical activity (PA) by rate of energy expenditure. It was developed to enhance the comparability of results across studies using self-reports of PA. The Compendium coding scheme links a five-digit code that describes physical activities by major headings (e.g., occupation, transportation, etc.) and specific activities within each major heading with its intensity, defined as the ratio of work metabolic rate to a standard resting metabolic rate (MET). Energy expenditure in MET-minutes, MET-hours, kcal, or kcal per kilogram body weight can be estimated for specific activities by type or MET intensity. Additions to the Compendium were obtained from studies describing daily PA patterns of adults and studies measuring the energy cost of specific physical activities in field settings. The updated version includes two new major headings of volunteer and religious activities, extends the number of specific activities from 477 to 605, and provides updated MET intensity levels for selected activities.
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            The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp.

            To meet the worldwide challenge of emerging diabetes, accessible and inexpensive tests to identify insulin resistance are needed. To evaluate the sensitivity and specificity of the product of fasting, we compared the triglycerides and glucose (TyG) index, a simple measure of insulin resistance, with the euglycemic-hyperinsulinemic clamp test. We conducted a cross-sectional study of the general population and outpatients of the Internal Medicine Department at the Medical Unit of High Specialty of the Specialty Hospital at the West National Medical Center in Guadalajara, Mexico. Eleven nonobese healthy subjects, 34 obese normal glucose tolerance individuals, 22 subjects with prediabetes, and 32 diabetic patients participated in the study. We performed a euglycemic-hyperinsulinemic clamp test. Sensitivity and specificity of the TyG index [Ln(fasting triglycerides) (mg/dl) x fasting glucose (mg/dl)/2] were measured, as well as the area under the curve of the receiver operating characteristic scatter plot and the correlation between the TyG index and the total glucose metabolism (M) rates. Pearson's correlation coefficient between the TyG index and M rates was -0.681 (P < 0.005). Correlation between the TyG index and M rates was similar between men (-0.740) and women (-0.730), nonobese (-0.705) and obese (-0.710), and nondiabetic (-0.670) and diabetic (-0.690) individuals. The best value of the TyG index for diagnosis of insulin resistance was 4.68, which showed the highest sensitivity (96.5%) and specificity (85.0%; area under the curve + 0.858). The TyG index has high sensitivity and specificity, suggesting that it could be useful for identification of subjects with decreased insulin sensitivity.
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              The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects.

              Because the insulin test is expensive and is not available in most laboratories in the cities of undeveloped countries, we tested whether the product of fasting triglycerides and glucose levels (TyG) is a surrogate for estimating insulin resistance compared with the homeostasis model assessment of insulin resistance (HOMA-IR) index. We performed a population-based cross-sectional study. Sampling strategy was based on a randomized two-stage cluster sampling procedure. Only apparently healthy subjects, men and nonpregnant women aged 18-65 years, with newly diagnosed impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or IFG + IGT were enrolled. Renal disease, malignancy, and diabetes were exclusion criteria. Sensitivity, specificity, predictive values, and the probability of disease given a positive test were calculated. The optimal TyG index for estimating insulin resistance was established using a receiver operating characteristic scatter plot analysis. A total of 748 apparently healthy subjects aged 41.4 +/- 11.2 years were enrolled. Insulin resistance was identified in 241 (32.2%) subjects (HOMA-IR index 4.4 +/- 1.6). New diagnoses of IFG, IGT, and IFG + IGT were established in 145 (19.4%), 54 (7.2%), and 75 (10.0%) individuals. respectively. The best TyG index for diagnosis of insulin resistance was Ln 4.65, which showed the highest sensitivity (84.0%) and specificity (45.0%) values. The positive and negative predictive values were 81.1% and 84.8%, and the probability of disease, given a positive test, was 60.5%. The TyG index could be useful as surrogate to identify insulin resistance in apparently healthy subjects.
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                Author and article information

                Journal
                jonnpr
                Journal of Negative and No Positive Results
                JONNPR
                Research and Science S.L. (Madrid, Madrid, Spain )
                2529-850X
                March 2023
                : 8
                : 1
                : 440-449
                Affiliations
                [2] Hermosillo Sonora orgnameCentro de Investigación en Alimentación y Desarrollo orgdiv1Departamento de Nutrición y Metabolismo, Coordinación de Nutrición México
                [1] Chihuahua orgnameUniversidad Autónoma de Chihuahua orgdiv1Facultad de Ciencias de la Cultura Física Mexico
                Article
                S2529-850X2023000100003 S2529-850X(23)00800100003
                10.19230/jonnpr.4886
                543e4984-2517-46c8-87f5-09dde6767e3f

                This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

                History
                : 05 September 2022
                : 22 November 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 16, Pages: 10
                Product

                SciELO Spain

                Categories
                Original

                TyG index,women,physical activity,insulin resistance,sedentary,HOMA-RI index

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