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      Excretion, distribution and metabolic fate of 3H-alpha-chaconine.

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      Research communications in chemical pathology and pharmacology

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          Abstract

          3H-alpha-Chaconine was poorly absorbed from the gastrointestinal tract and rapidly excreted in feces when administered orally to male rats. Intraperitoneal administration of low doses (5 to 10 mg/kg) resulted in urinary and fecal excretion of metabolites, and probably involved biliary excretion. High, toxic, intraperitoneal doses (15 to 25 mg/kg) depressed fecal and urinary elimination, and resulted in accumulation of tritium in various tissues. The major metabolite appeared to be the aglycone, solanidine. Alpha-chaconine is very similar to alpha-solanine in its elimination by and distribution in tissues of rats.

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          Author and article information

          Journal
          Res. Commun. Chem. Pathol. Pharmacol.
          Research communications in chemical pathology and pharmacology
          0034-5164
          0034-5164
          Feb 1976
          : 13
          : 2
          Article
          1257605
          54403fd5-6321-4a6f-95b2-5061d2746401
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