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Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma.

Author(s): Jonathan G. Sham, Forrest M. Kievit, John R Grierson, Robert S. Miyaoka, Matthew Yeh, Miqin Zhang, Raymond S Yeung, Satoshi Minoshima, James O. Park

Publication date: 2014-05-01

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Publisher: Society of Nuclear Medicine

Keywords: glypican 3, liver, hepatocellular carcinoma, PET, 89Zr

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Abstract

Hepatocellular carcinoma (HCC) is a devastating malignancy in which imperfect imaging plays a primary role in diagnosis. Glypican-3 (GPC3) is an HCC-specific cell surface proteoglycan overexpressed in most HCCs. This paper presents the use of (89)Zr-conjugated monoclonal antibody against GPC3 ((89)Zr-αGPC3) for intrahepatic tumor localization using PET.

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PubMed ID:: 24627434

PMC ID:: 4116087

DOI:: 10.2967/jnumed.113.132118

Keywords: glypican 3,liver,hepatocellular carcinoma,PET,89Zr

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Keywords: glypican 3, liver, hepatocellular carcinoma, PET, 89Zr

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