Eric Song:
ORCID: https://orcid.org/0000-0001-5448-5865
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole:
Writing - review & editing
Ce Zhang:
ORCID: https://orcid.org/0000-0002-2736-8791
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: VisualizationRole: Writing - original draftRole: Writing - review &
editing
Benjamin Israelow:
ORCID: https://orcid.org/0000-0002-1308-8246
Role: InvestigationRole: MethodologyRole: Resources
Alice Lu-Culligan:
ORCID: https://orcid.org/0000-0003-0097-0923
Role: InvestigationRole: Methodology
Alba Vieites Prado:
ORCID: https://orcid.org/0000-0002-8807-3321
Role: Investigation
Sophie Skriabine:
ORCID: https://orcid.org/0000-0003-1733-515X
Role: Formal analysis
Peiwen Lu:
ORCID: https://orcid.org/0000-0001-6118-872X
Role: Investigation
Orr-El Weizman:
ORCID: https://orcid.org/0000-0002-1132-8170
Role: Investigation
Feimei Liu:
ORCID: https://orcid.org/0000-0003-2663-6544
Role: Data curationRole: Investigation
Yile Dai:
ORCID: https://orcid.org/0000-0002-7761-3361
Role: Investigation
Klara Szigeti-Buck:
ORCID: https://orcid.org/0000-0002-9428-8820
Role: Investigation
Yuki Yasumoto:
ORCID: https://orcid.org/0000-0001-9882-4478
Role: Data curationRole: Visualization
Guilin Wang:
ORCID: https://orcid.org/0000-0002-7835-3186
Role: Formal analysisRole: MethodologyRole: Resources
Christopher Castaldi:
ORCID: https://orcid.org/0000-0003-4880-801X
Role: Data curation
Jaime Heltke:
ORCID: https://orcid.org/0000-0002-1605-6119
Role: InvestigationRole: Resources
Evelyn Ng:
ORCID: https://orcid.org/0000-0002-3954-6292
Role: Investigation
John Wheeler:
ORCID: https://orcid.org/0000-0002-5786-3718
Role: Investigation
Mia Madel Alfajaro:
ORCID: https://orcid.org/0000-0002-6402-2730
Role: Investigation
Etienne Levavasseur:
ORCID: https://orcid.org/0000-0002-5827-2952
Role: Resources
Benjamin Fontes:
ORCID: https://orcid.org/0000-0001-6576-5432
Role: Project administrationRole: Resources
Neal G. Ravindra:
ORCID: https://orcid.org/0000-0001-5558-3758
Role: Formal analysisRole: MethodologyRole: SoftwareRole: Visualization
David Van Dijk:
ORCID: https://orcid.org/0000-0003-3911-9925
Role: Supervision
Shrikant Mane:
ORCID: https://orcid.org/0000-0002-3267-5139
Role: MethodologyRole: Resources
Murat Gunel:
ORCID: https://orcid.org/0000-0002-2290-7055
Role: Resources
Aaron Ring:
ORCID: https://orcid.org/0000-0003-3699-2446
Role: Funding acquisitionRole: Project administrationRole: Supervision
Syed A. Jaffar Kazmi:
ORCID: https://orcid.org/0000-0002-1577-8419
Role: ResourcesRole: Validation
Kai Zhang:
ORCID: https://orcid.org/0000-0002-5274-3194
Role: ResourcesRole: Validation
Craig B. Wilen:
ORCID: https://orcid.org/0000-0003-2495-9403
Role: Funding acquisitionRole: ResourcesRole: Writing - review & editing
Tamas L. Horvath:
ORCID: https://orcid.org/0000-0002-7522-4602
Role: InvestigationRole: SupervisionRole: Validation
Isabelle Plu:
ORCID: https://orcid.org/0000-0002-1956-0150
Role: InvestigationRole: Resources
Stephane Haik:
ORCID: https://orcid.org/0000-0001-6022-1188
Role: InvestigationRole: ResourcesRole: Writing - review & editing
Jean-Leon Thomas:
ORCID: https://orcid.org/0000-0003-3397-0292
Role: ResourcesRole: Writing - review & editing
Angeliki Louvi:
ORCID: https://orcid.org/0000-0003-1737-8707
Role: SupervisionRole: Writing - review & editing
Shelli F. Farhadian:
ORCID: https://orcid.org/0000-0001-7230-1409
Role: Funding acquisitionRole: ResourcesRole: Writing - review & editing
Anita Huttner:
ORCID: https://orcid.org/0000-0003-2143-4329
Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing - review &
editing
Danielle Seilhean:
ORCID: https://orcid.org/0000-0003-3498-4602
Role: InvestigationRole: Resources
Nicolas Renier:
ORCID: https://orcid.org/0000-0003-2642-4402
Role: Data curationRole: Formal analysisRole: InvestigationRole: ResourcesRole: SoftwareRole:
SupervisionRole: ValidationRole: Visualization
Kaya Bilguvar:
ORCID: https://orcid.org/0000-0002-7313-7652
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
SupervisionRole: Writing - original draftRole: Writing - review & editing
Akiko Iwasaki:
ORCID: https://orcid.org/0000-0002-7824-9856
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: Writing - review & editing
Journal ID (nlm-ta): J Exp Med
Journal ID (iso-abbrev): J Exp Med
Journal ID (publisher-id): jem
Title:
The Journal of Experimental Medicine
Publisher:
Rockefeller University Press
ISSN
(Print):
0022-1007
ISSN
(Electronic):
1540-9538
Publication date Collection: 01
March
2021
Publication date
(Electronic):
12
January
2021
Publication date PMC-release: 12
January
2021
Volume: 218
Issue: 3
Electronic Location Identifier: e20202135
Affiliations
[1
]Department of Immunobiology, Yale School of Medicine, New Haven, CT
[2
]Department of Genetics, Yale School of Medicine, New Haven, CT
[3
]Department of Neuroscience, Yale School of Medicine, New Haven, CT
[4
]Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine,
New Haven, CT
[5
]Sorbonne Université, INSERM U1127, French National Centre for Scientific Research,
Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle
Épinière, Paris, France
[6
]Department of Biomedical Engineering, Yale University, New Haven, CT
[7
]Department of Comparative Medicine, Yale School of Medicine, New Haven, CT
[8
]Yale Center for Genome Analysis, West Haven, CT
[9
]Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT
[10
]Yale Environmental Health and Safety, Yale University, New Haven, CT
[11
]Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of
Internal Medicine, Yale School of Medicine, New Haven, CT
[12
]Department of Computer Science, Yale University, New Haven, CT
[13
]Department of Neurosurgery, Yale School of Medicine, New Haven, CT
[14
]Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA
[15
]Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine,
New Haven, CT
[16
]Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département de Neuropathologie,
Paris, France
[17
]Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Cellule nationale
de référence des maladies de Creutzfeldt-Jakob, Paris, France
[18
]Department of Neurology, Yale School of Medicine, New Haven, CT
[19
]Department of Pathology, Yale School of Medicine, New Haven, CT
[20
]Howard Hughes Medical Institute, Chevy Chase, MD
Author notes
Disclosures: M. Gunel reported personal fees from AI Therapeutics outside the submitted
work; and reported, "AI Therapeutics is currently sponsoring a clinical trial for
a therapeutic, which has no relevance for this study, in COVID-19. I am the Chief
Scientific Advisor to AI Therapeutics." C.B. Wilen reported personal fees from ZymoResearch
outside the submitted work; in addition, C.B. Wilen had a patent for compounds and
compositions for treating, ameliorating, and/or preventing SARS-CoV-2 infection and/or
complications thereof pending. S. Haik reported a patent to Method for treating prion
diseases (PCT/EP 2019/070457) pending. A. Iwasaki reported "other" from RIGImmune
and grants from Spring Discovery during the conduct of the study; in addition, A.
Iwasaki had a patent to 14/776,463 pending, a patent for a T cell-based immunotherapy
for central nervous system viral infections and tumors pending, and a patent to manipulation
of meningeal lymphatic vasculature for brain and CNS tumor therapy pending. No other
disclosures were reported.
[*]
E. Song and C. Zhang contributed equally to this paper.
Author information
Article
Publisher ID:
jem.20202135
DOI: 10.1084/jem.20202135
PMC ID: 7808299
PubMed ID: 33433624
SO-VID: 546edb94-b53b-4735-9185-cb3fd26fb8a7
Copyright © © 2021 Song et al.
License:
This article is distributed under the terms of an Attribution–Noncommercial–Share
Alike–No Mirror Sites license for the first six months after the publication date
(see
http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share
Alike 4.0 International license, as described at
https://creativecommons.org/licenses/by-nc-sa/4.0/).
Funded by: National Institutes of Health, DOI http://dx.doi.org/10.13039/100000002;
Award ID: R01AI157488
Award ID: R01NS111242
Award ID: T32GM007205
Award ID: F30CA239444
Award ID: 2T32AI007517
Award ID: K23MH118999
Funded by: Yale University, DOI http://dx.doi.org/10.13039/100005326;
Funded by: Emergent Ventures at the Mercatus Center;
Funded by: Mathers Foundation, DOI http://dx.doi.org/10.13039/100011671;
Funded by: Ludwig Family Foundation;
Funded by: Howard Hughes Medical Institute, DOI http://dx.doi.org/10.13039/100000011;