Infertility problems can lower the quality of life (QoL). This study aims to predict the factors associated with QoL using the Malaysian FertiQoL. This cross-sectional study was conducted at four fertility clinics in Malaysia. Sociodemographic details and FertiQoL responses were collected. A total of 395 participants were analysed using SPSS v24 with a mean (SD) age of 33.18 (4.45). Respondents were predominantly female (57.2%) and Malay ethnicity (82.5%). The core domain means score (SD) was 74.68 (14.35) and consisted of mind-body 77.56 (17.55), emotional 70.26 (18.98), relational 77.32 (17.19) and social 73.56 (15.74). Positive predictors for QoL are Islamic faith, higher income, and general well-being.