All countries in the European Community face common challenges for delivering appropriate
and high-quality care to patients with cancer. However, despite tangible improvements
in diagnosis and treatment, marked differences in cancer survival across European
regions exist (Sant et al, 2001).
The translation of existing research results into consistent patient-oriented strategies
in the form of evidence reviews is a key endeavour to help improve cancer care and
patient outcomes. Clinical practice guidelines (CPGs) are important tools for informing
health-care professionals and patients about appropriate clinical practice in cancer
care. Numerous guidelines development programmes have been set up in most European
countries to develop CPGs in various specialities, including oncology (Courté-Wienecke
et al, 1999).
However, recent studies have shown that published guidelines vary in quality (Shaneyfelt
et al, 1999; Grilli et al, 2000; Graham et al, 2001) and some may even recommend suboptimal
care. It has been established that it is essential that CPGs are evidence-based, so
as to provide a valid tool for those caring for patients with cancer. To be credible,
CPGs should also be developed with the input of local multidisciplinary cancer specialists
(Ray-Coquard et al, 1997,Ray-Coquard et al, 2002) to encourage local acceptance and
use in clinical practice.
In addition to the process of development, guideline ‘after-care’, i.e. the combination
of dissemination, implementation and guideline updating, has been recognised as being
important to the success of guidelines (Browman, 2001a,Browman, 2001b). Some oncology
CPGs have been shown to lead to significant changes in practice when dissemination
and implementation are conceptualised from the beginning of the guideline development
process (Ray-Coquard et al, 1997,Ray-Coquard et al, 2002; Fervers et al, 2001b).
The development, updating and implementation of high-quality CPGs require substantial
resources, both in terms of time and money. Currently, there is no systemic and structured
approach to the development, evaluation and monitoring of guidelines at the international
level. Moreover, there is no infrastructure to sustain and further develop these efforts.
As a result, efforts are unnecessarily duplicated by organisations in different countries
aiming at similar goals and using similar strategies. This may result in the wastage
of financial and structural resources, and the suboptimal management of activities.
These resources include the time volunteered by experts who participate in the working
groups.
European countries could benefit from a multinational European collaboration for guidelines
development, to minimise costs and avoid existing unnecessary duplication of effort,
and to improve the dissemination and implementation of CPGs that comply with internationally
accepted quality criteria.
If a multinational collaboration for CPG development is to be set up, it should be
built on existing CPGs initiatives involved in the development of CPGs in oncology.
However, the CPGs initiatives in different countries use different methodological
approaches. These differences can be explained, partly, by the differing reasons for
guideline development and the characteristics of organisations involved in the CPG
development process (Burgers et al, 2003). One major difference, for example, is the
choice between a ‘top down’ strategy, organised by national (or regional) agencies,
and a ‘bottom up’ strategy, based on professional initiative. Based on this diversity,
the experiences of the various initiatives are heterogeneous, as shown by an international
survey of 19 guidelines programmes. This situation yields a series of challenges that
should be addressed and also raises questions that must be answered when setting up
a multinational collaboration.
To ensure that CPGs will contribute to the improvement of care for cancer patients,
CPG development and the reporting of that process should meet specific quality criteria
(Grol et al, 2003). The different dimensions of guideline quality that have been developed
and validated recently by the Appraisal of Guidelines, Research and Evaluation (AGREE)
Collaboration (funded under the European Union Biomed II Research Programme) provide
a framework for the development of guidelines at the international level (www.agreecollaboration.org).
These dimensions include the rigour of the methods used to collect and synthesise
the evidence, the process used to formulate the recommendations, the involvement of
stakeholders and the applicability of the recommendations.
Quality assessment of guidelines using the AGREE instrument showed that CPGs produced
as part of a structured programme had significantly higher quality scores than those
published outside such programmes (AGREE Collaboration, 2003). As a consequence, multinational
cooperative projects could provide appropriate infrastructure and the environment
for sharing specific tasks in the CPGs development and updating processes as well
as the dissemination and implementation processes. This includes methodological support
at all levels and well-defined procedures for sharing responsibilities.
A systemic approach is the basis for identifying which aspects of the guidelines development
process can be achieved in common on a European or international level, and which
aspects require specific national and local input. Literature searching, critical
appraisal and synthesis of the evidence are key elements in the guideline development
and updating processes. They are also the most costly and time-consuming steps in
the path from research results to evidence-informed recommendations. Although some
of the key elements in the guidelines development and updating process should give
consistent results, the cultural diversity among European countries, particularly
in terms of the structure and organisation of care, can lead to legitimate variability
in guideline recommendations (Fervers et al, 1997; Eisinger et al, 1999). This includes
variations due to cost-considerations in reimbursement strategies and policy-making
decisions (Mille et al, 2000).
The collaboration between the guidelines project ‘Standards, Options and Recommendations’
(SOR), run by the French National Federation of Cancer Centres (FNCLCC) (Fervers et
al, 2001a), the OECI (European Organisation of Cancer Centres) and the Cancer Care
Ontario Guidelines Initiative (CCOPGI) (Browman et al, 1995) has provided good insight
into the challenges encountered when different countries cooperate. In particular,
the collaboration between the SOR and the CCOPGI has helped our understanding of the
legitimate reasons for discrepancies between guideline recommendations based on the
same evidence, due to national and medical cultural differences (Browman, 2001a; Fervers
et al, 2001b; Burgers et al, 2003). However, further research is needed to understand
and to develop an explicit approach for consideration of cultural and contextual considerations
in the formulation of the recommendations.
Multinational cooperation should ensure that shared guidelines are relevant to national
and local situations. This is crucial for the successful implementation of the guidelines
and can be achieved by formulating the recommendations under national or local responsibility.
The involvement of national and local stakeholders in the field of cancer from the
participating countries will contribute to the enhancement of the local pertinence
and acceptance of shared CPGs. The cultural diversity in Europe highlights the need
for a transparent and explicit guidelines development process, in particular how recommendations
are produced, with a clear link between the evidence and the recommendations, and
information on how practitioners and other stakeholders are involved in the process.
A process based on the Guidelines Development Cycle published by Browman et al (1995)
provides a means of achieving both generalisable evidence-based recommendations and
local relevance for practice (Figure 1
Figure 1
Framework for shared development of evidence-based clinical practice guidelines with
local relevance. Reprinted with permission from Elsevier (The Lancet Oncology 2003;
4; 139–40)
).
To achieve the objectives of CPGs, multinational collaboration should ensure accessibility
of CPGs through appropriate dissemination and implementation strategies and by using
different formats. These strategies should be tailored to the different target audiences
involved in medical decision making (clinicians, policy makers, patients and other
citizens) and clinical settings in the participating countries.
These observations, including the unnecessary duplication of effort among existing
guideline initiatives, have led to an examination of how a multinational cooperative
and structured approach to guideline development and updating, dissemination and implementation
could be achieved in Europe (Fervers et al, 2002, http://eoi.cordis.lu/dsp_details.cfm?ID=29033).
In Europe, as elsewhere, the reliability and sustainability of guidelines development
programmes is an unquestionable challenge. To provide added value to existing guideline
initiatives in Europe, the proposed multinational collaboration should aim to share
existing experiences while taking into account the cultural and organisational diversity
of the participating organisations and countries. This is important if national relevance
and acceptance by guideline users are to be achieved, and if shared CPGs are to influence
clinical practice. This has been shown to be crucial for the Canadian initiative when
a national guidelines oncology programme for approval of new drugs was set up, involving
the different provinces. In Europe, the different languages of the various European
countries will add a level of complexity to this undertaking.
Promoting collaboration among guideline development initiatives in Europe will involve
learning how we can build on existing initiatives and how we can adopt common standards
to improve the consistency and quality of the guidelines. We will also have to learn
how to share CPG development and updating responsibilities at an international level,
and how to identify which responsibilities should be delegated to the national and
local levels. Also, we need to learn how to increase the national relevance and local
acceptance of shared guidelines, how to identify appropriate mechanisms for collaboration
and how to provide an appropriate organisational framework for the shared development
and updating of CPGs. The process will also involve identifying mechanisms for the
development of related information for patients and their families, cancer advocacy
groups and other citizens.
A proposal to set up a multinational collaboration for the development of cancer clinical
practice guidelines is currently being elaborated. An outline proposal was submitted
to the recent call for ‘Expression of Interest’ that was launched by the European
union in the setting of its Sixth Framework programme for funding research (http://www.cordis.lu/fp6/).
This collaboration will involve some members of the AGREE collaboration, a network
of health services, research institutions and guidelines development organisations
from 17 countries in Europe, USA, Canada and Asia-Pacific countries, and some of the
partners in a network of European organisations working in the field of cancer, cancer
centres (via OECI), professional societies and cancer-care specialists. This proposed
multinational collaboration will make a significant contribution to avoiding duplication
of effort and ensuring the availability of high-quality CPGs. This, in turn, will
give individual health professionals better access to modern standards of clinical
practice and thus contribute to improving care for cancer patients. Enabling patients
and other citizens to understand cancer and its treatment better will improve their
quality of life and help them to learn to live better with cancer.
In addition, multinational collaboration based on these principles will provide an
excellent opportunity to explore the influence of culture and values in the path from
scientific evidence to the final recommendation, and ultimately to patterns of practice.
This will lead to a better understanding of the key elements in the guideline development
process, and the impact of social, ethical and cultural issues on the effective dissemination
and use of CPGs.