Objective. To explore the influence of predictive nursing combined with emotional therapy on the rehabilitation effect and psychological state of patients with brain injury after the operation and to analyze its application value to patients with brain injury after the operation. Methods. 70 postoperative patients with brain injury who went to our hospital for diagnosis and treatment were selected as the key figures of this experiment, including 31 female patients and 39 male patients. In order to ensure the uniformity of data, medical staff need to divide patients into an experimental group and a control group through the double-blind method, with 35 cases in each group. The patients in the two groups need to take the relevant diagnosis and surgical treatment measures after admission. The patients in the control group take routine nursing, providing patients with a clean and tidy ward is convenient for patients to manage nursing, and for patients to bring comfortable treatment relief. The patients in the experimental group take predictive nursing combined with emotional therapy, which is to master the basic situation of patients, according to the quality of patients, and develop comprehensive nursing measures for patients. The psychological status, complication incidence rate, treatment effectiveness, and nursing satisfaction of the two groups were compared and analyzed. Results. The psychological status, complication incidence rate, nursing efficiency, and nursing satisfaction of patients in the experimental group were significantly better than those in the control group (P < 0.05). Conclusion. Predictive nursing combined with emotional therapy for patients with brain injury after the operation can effectively alleviate bad mood of patients, reduce the incidence rate of complications, improve the nursing satisfaction of patients, as well as provide patients with high-quality treatment and nursing services. It has a certain clinical application value and is worth popularizing.