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      Prevalence of Primary Cornea guttata and Morphology of Corneal Endothelium in Aging Japanese and Singaporean Subjects

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          Abstract

          The purpose of the present study was to examine, in the aging people, racial and gender differences in the morphology of corneal endothelium as well as the incidence of cornea guttata in two Asian subject groups, one in Singapore and the other in Japan. Four hundred and sixty-five Chinese Singaporeans and 299 Japanese subjects (residents of Monzen-machi, Ishikawa Prefecture) aged 50 years and older were recruited for the study. Corneal endothelial abnormalities were diagnosed with slit-lamp biomicroscopy and specular microscopy. Primary cornea guttata appeared as beaten metal appearance in slit-lamp images and dark regions in specular images. In addition to cornea guttata, corneal endothelial morphology was also analysed with specular microscopy. The mean cell density was 2,808/mm<sup>2</sup> in the Japanese subjects which was significantly higher than the 2,718/mm<sup>2</sup> seen in the Singaporeans (p < 0.001). The incidence of cornea guttata was significantly higher in the Singaporeans than in the Japanese individuals and also higher in women than in men of both racial groups. These differences support not only a racial and a gender factor but also a possible environmental influence.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          2002
          June 2002
          28 June 2002
          : 34
          : 3
          : 135-138
          Affiliations
          Departments of aOphthalmology and bPublic Health, Kanazawa Medical University, Ishikawa, Japan; cSingapore Eye Research Institute, Singapore National Eye Centre, Singapore; dSchepens Eye Associates and Retina Associates Foundation, Boston, Mass., and eDepartment of Ophthalmology and Vision Science, Washington University Medical School, St.Louis,Mo.,USA; fEpidemiology and International Health Research Section, Environmental Health Science Division, National Institute for Environmental Studies, Tsukuba, Japan
          Article
          63656 Ophthalmic Res 2002;34:135–138
          10.1159/000063656
          12097795
          © 2002 S. Karger AG, Basel

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          Page count
          Figures: 1, Tables: 1, References: 15, Pages: 4
          Categories
          Original Paper

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