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      Logic‐Based Delivery of Site‐Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials

      1 , 1 , 1 , 1 , 2 , 3
      Advanced Materials
      Wiley

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          Most cited references36

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          Photodegradable hydrogels for dynamic tuning of physical and chemical properties.

          We report a strategy to create photodegradable poly(ethylene glycol)-based hydrogels through rapid polymerization of cytocompatible macromers for remote manipulation of gel properties in situ. Postgelation control of the gel properties was demonstrated to introduce temporal changes, creation of arbitrarily shaped features, and on-demand pendant functionality release. Channels photodegraded within a hydrogel containing encapsulated cells allow cell migration. Temporal variation of the biochemical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells. Photodegradable gels that allow real-time manipulation of material properties or chemistry provide dynamic environments with the scope to answer fundamental questions about material regulation of live cell function and may affect an array of applications from design of drug delivery vehicles to tissue engineering systems.
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            Hydrogels for protein delivery.

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              Cytocompatible Click-based Hydrogels with Dynamically-Tunable Properties Through Orthogonal Photoconjugation and Photocleavage Reactions

              To provide insight as to how cells receive information from their external surroundings, synthetic hydrogels have emerged as systems for assaying cell function in well-defined microenvironments where single cues can be introduced and subsequent effects individually elucidated. However, as the field seeks to answer more complex biological questions, advanced material systems are needed that allow dynamic alteration of the 3D cellular environment with orthogonal reactions that enable multiple levels of control of biochemical and biomechanical signals. Here, we sought to synthesize one such 3D culture system using cytocompatible and wavelength-specific photochemical reactions to create hydrogels that allow orthogonal and dynamic control of the material properties through independent spatiotemporally-regulated photocleavage of crosslinks and photoconjugation of pendant functionalities. Results demonstrate the versatile nature of the chemistry to create programmable niches to study and direct cell function by modifying the local hydrogel environment.
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                Author and article information

                Journal
                Advanced Materials
                Adv. Mater.
                Wiley
                0935-9648
                1521-4095
                June 25 2019
                August 2019
                July 02 2019
                August 2019
                : 31
                : 33
                : 1902462
                Affiliations
                [1 ]Department of Chemical EngineeringUniversity of Washington 3781 Okanogan Lane NE Seattle WA 98195 USA
                [2 ]Department of BioengineeringUniversity of Washington 3720 15th Ave NE Seattle WA 98105 USA
                [3 ]Institute for Stem Cell and Regenerative MedicineUniversity of Washington 850 Republican Street Seattle WA 98109 USA
                Article
                10.1002/adma.201902462
                54e59551-31f8-4ce8-b839-f2f582c0d015
                © 2019

                http://onlinelibrary.wiley.com/termsAndConditions#am

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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