Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma

Read this article at

Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      The polypeptide N-acetylgalactosaminyltransferase (GalNAc-Ts) family of enzymes regulates the critical initial steps of mucin-type O-glycosylation. Among GalNAc-Ts that may significantly influence cancer biology, thus affecting cell differentiation, adhesion, invasion, and/or metastasis, GalNAc-T3 exhibits a high expression in several human cancers, closely associated with tumor progression and a poor prognosis. However, the expression pattern of GalNAc-T3 in oral squamous cell carcinoma (OSCC) remains obscure. Since postoperative recurrence of even early stage OSCC (ESOSCC) occurs at an early phase, significantly affecting their clinical course and worse outcome, the identification of clinically significant accurate biomarkers is needed. Therefore, we investigated the correlation between the immunohistochemical GalNAc-T3 expression and various clinicopathological characteristics and recurrence using 110 paraffin-embedded tumor samples obtained from patients with surgically resected ESOSCC (T1–2N0). Recurrence was recognized in 37 of 110 (33.6 %) patients. The GalNAc-T3 expression was considered to be strongly positive when 20 % or more of the cancer cells showed positive cytoplasmic staining. Consequently, a strong expression of GalNAc-T3 was observed in 40 patients (36.4 %), showing a close relationship to poor differentiation, the presence of lymphatic and vascular invasion, and recurrence. Univariate and multivariate analyses further demonstrated that the patients with a strong GalNAc-T3+ status had markedly lower disease-free survival (DFS) rates, especially within the first 2 years postoperatively. Therefore, GalNAc-T3 might play a role in the pathogenesis of ESOSCC recurrence, and its immunohistochemical detection potentially predicts a shorter DFS and may be a useful parameter for providing clinical management against ESOSCC in the early postoperative phase.Electronic supplementary materialThe online version of this article (doi:10.1007/s13277-015-3928-7) contains supplementary material, which is available to authorized users.

      Related collections

      Most cited references 37

      • Record: found
      • Abstract: found
      • Article: found

      Global cancer statistics.

      The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors, particularly smoking, in economically developing countries. Based on the GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008; of these, 56% of the cases and 64% of the deaths occurred in the economically developing world. Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Lung cancer is the leading cancer site in males, comprising 17% of the total new cancer cases and 23% of the total cancer deaths. Breast cancer is now also the leading cause of cancer death among females in economically developing countries, a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Further, the mortality burden for lung cancer among females in developing countries is as high as the burden for cervical cancer, with each accounting for 11% of the total female cancer deaths. Although overall cancer incidence rates in the developing world are half those seen in the developed world in both sexes, the overall cancer mortality rates are generally similar. Cancer survival tends to be poorer in developing countries, most likely because of a combination of a late stage at diagnosis and limited access to timely and standard treatment. A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination (for liver and cervical cancers), and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake. Clinicians, public health professionals, and policy makers can play an active role in accelerating the application of such interventions globally.
        Bookmark
        • Record: found
        • Abstract: not found
        • Article: not found

        Toxicity and response criteria of the Eastern Cooperative Oncology Group.

          Bookmark
          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Investigation of the freely available easy-to-use software ‘EZR' for medical statistics

           Y Kanda (2012)
          Although there are many commercially available statistical software packages, only a few implement a competing risk analysis or a proportional hazards regression model with time-dependent covariates, which are necessary in studies on hematopoietic SCT. In addition, most packages are not clinician friendly, as they require that commands be written based on statistical languages. This report describes the statistical software ‘EZR' (Easy R), which is based on R and R commander. EZR enables the application of statistical functions that are frequently used in clinical studies, such as survival analyses, including competing risk analyses and the use of time-dependent covariates, receiver operating characteristics analyses, meta-analyses, sample size calculation and so on, by point-and-click access. EZR is freely available on our website (http://www.jichi.ac.jp/saitama-sct/SaitamaHP.files/statmed.html) and runs on both Windows (Microsoft Corporation, USA) and Mac OS X (Apple, USA). This report provides instructions for the installation and operation of EZR.
            Bookmark

            Author and article information

            Affiliations
            [ ]Department of Pathology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555 Japan
            [ ]Department of Dentistry and Oral Surgery, University Hospital of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Department of Occupational Pneumology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Department of Second Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Department of Urology, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Shared-Use Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan
            [ ]Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka, 811-0213 Japan
            [ ]Department of Oral and Maxillofacial Surgery, Field of Oral and Maxillofacial Rehabilitation, Advanced Therapeutics Course, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima 890-8520 Japan
            [ ]Asahi-Matsumoto Hospital, Kitakyushu, 800-0242 Japan
            [ ]Institute of Pathology, Medical University of Graz, Graz, 8010 Austria
            [ ]Institute of Molecular Biosciences, University of Graz, Graz, 8010 Austria
            Contributors
            ORCID: http://orcid.org/0000-0003-2662-0024, 81-93-691-7240 , sousuke@med.uoeh-u.ac.jp
            Journal
            Tumour Biol
            Tumour Biol
            Tumour Biology
            Springer Netherlands (Dordrecht )
            1010-4283
            1423-0380
            22 August 2015
            22 August 2015
            January 2016
            : 37
            : 1
            : 1357-1368
            26296622
            4841842
            3928
            10.1007/s13277-015-3928-7
            © The Author(s) 2015

            Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

            Categories
            Original Article
            Custom metadata
            © International Society of Oncology and BioMarkers (ISOBM) 2016

            Comments

            Comment on this article