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      Extracellular matrix degradation and remodeling in development and disease.

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          Abstract

          The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture. ECM remodeling is an important mechanism whereby cell differentiation can be regulated, including processes such as the establishment and maintenance of stem cell niches, branching morphogenesis, angiogenesis, bone remodeling, and wound repair. In contrast, abnormal ECM dynamics lead to deregulated cell proliferation and invasion, failure of cell death, and loss of cell differentiation, resulting in congenital defects and pathological processes including tissue fibrosis and cancer. Understanding the mechanisms of ECM remodeling and its regulation, therefore, is essential for developing new therapeutic interventions for diseases and novel strategies for tissue engineering and regenerative medicine.

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          Author and article information

          Journal
          Cold Spring Harb Perspect Biol
          Cold Spring Harbor perspectives in biology
          Cold Spring Harbor Laboratory
          1943-0264
          1943-0264
          Dec 01 2011
          : 3
          : 12
          Affiliations
          [1 ] Breakthrough Breast Cancer Research Unit, Paterson Institute for Cancer Research and Wellcome Trust Centre for Cell Matrix Research, University of Manchester, United Kingdom.
          Article
          cshperspect.a005058 NIHMS429862
          10.1101/cshperspect.a005058
          3225943
          21917992
          54f69488-71b0-4442-931b-552016a8c966
          History

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