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Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.
Matthew K Robinson
1 ,
Calvin Shaller ,
Kayhan Garmestani ,
Paul S Plascjak ,
Kathryn M Hodge ,
Qing-An Yuan ,
James D Marks ,
Thomas A Waldmann ,
Martin W Brechbiel ,
Gregory P Adams
Feb 01 2008
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Abstract
Successful radioimmunotherapy strategies depend on selecting radioisotopes with physical properties complementary to the biological properties of the targeting vehicle. Small, engineered antitumor antibody fragments are capable of rapid, highly specific tumor targeting in immunodeficient mouse models. We hypothesized that the C6.5 diabody, a noncovalent anti-HER2 single-chain Fv dimer, would be an ideal radioisotope carrier for the radioimmunotherapy of established tumors using the short-lived alpha-emitting radioisotope (211)At.