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      Neuropeptide Y: Distribution of Immunoreactivity and Quantitative Analysis in Diencephalic Structures and Cerebral Cortex of Dwarf Hamsters under Different Photoperiods

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          Abstract

          The distribution of neuropeptide Y-like immunoreactivity (NPY-LI) was investigated by immunohistochemistry and radioimmunoassay (RIA) in the brain of the Djungarian hamster ( Phodopus sungorus) held under either long or short photoperiods. In the diencephalic and telencephalic structures studied, distinct patterns of NPY-LI were basically consistent in male and female animals of both groups. NPY levels detected by RIA from tissue samples taken at six time points throughout the 24-hour cycle were in the range of 15-60 pmol/ mg protein in the diencephalon or below 5 pmol/mg protein in cerebral cortex. In the diencephalon, immunoreactive structures were seen in the preoptic, peri- and paraventricular, supraoptic, anterior, lateral, dorso- and ventromedial hypothalamic nuclei and in the median eminence. The suprachiasmatic nuclei exhibited a dense innervation by NPY-LI terminals mainly in its ventrolateral subdivision. NPY levels in the suprachiasmatic nucleus were nocturnal-ly augmented under long-day, but not under short-day conditions. The quantification of NPY in the paraventricular nucleus revealed a decrease at night in long-day animals and a small nocturnal augmentation in short-day hamsters. In the pineal gland and habenular nuclei, varicose fibers were observed which appeared mainly perivascular in location (pineal) or formed a dense plexus (habenular nuclei). Pineal NPY contents fell during the night in long-day animals and were relatively constant in short-day hamsters. NPY-LI structures were also observed in the metathalamic intergeniculate leaflet and in a variety of telencephalic structures including the cerebral cortex, caudate nucleus puta-men, lateral septal nucleus, bed nucleus of the stria terminalis and amygdala.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1995
          1995
          09 April 2008
          : 61
          : 4
          : 337-347
          Affiliations
          Department of Anatomy, Johannes Gutenberg University, Mainz, and Institute for Hormone and Fertility Research, Hamburg, Germany
          Article
          126856 Neuroendocrinology 1995;61:337–347
          10.1159/000126856
          7783848
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Distribution and Effects of Neuropeptides or Neurotransmitters

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