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      Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway.

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          Abstract

          Mononuclear cell infiltration in valvular tissue is one of the characteristics in calcific aortic valve disease. The inflammatory responses of aortic valve interstitial cells (AVICs) play an important role in valvular inflammation. However, it remains unclear what may evoke AVIC inflammatory responses. Accumulation of biglycan has been found in diseased aortic valve leaflets. Soluble biglycan can function as a danger-associated molecular pattern to induce the production of proinflammatory mediators in cultured macrophages. We tested the hypothesis that soluble biglycan induces AVIC production of proinflammatory mediators involved in mononuclear cell infiltration through Toll-like receptor (TLR)-dependent signaling pathways.

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          Author and article information

          Journal
          Inflamm. Res.
          Inflammation research : official journal of the European Histamine Research Society ... [et al.]
          1420-908X
          1023-3830
          Sep 2014
          : 63
          : 9
          Affiliations
          [1 ] Department of Surgery, University of Colorado Denver, 12700 E 19th Avenue, Box C-320, Aurora, CO, 80045, USA.
          Article
          NIHMS600338
          10.1007/s00011-014-0743-3
          4134418
          24875140
          55096378-d02c-4998-8b56-c883798a06f6
          History

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