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Mast cell leukemia (MCL): Clinico-pathologic and molecular features and survival outcome
Preetesh Jain ,
Sa Wang ,
Keyur P. Patel ,
Nawid Sarwari ,
Jorge Cortes ,
Hagop Kantarjian ,
Srdan Verstovsek
August 2017
August 2017
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Abstract
<p class="first" id="P1">Mast cell leukemia (MCL) is a very rare subtype of systemic
mastocytosis (SM). We
have identified 13 such patients (5.9%) among 218 patients with SM seen at our institution
between 1994 and 2016. Patients with MCL had poor survival (median 31.6 months); response
to various therapies was rare and not durable. Clinical course may be affected by
concurrent associated hematologic neoplasm and different genetic profiles. More research
is required to decipher this rare and enigmatic SM subtype.
</p>