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Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.
Stefan Leucht
1 ,
Andrea Cipriani ,
Loukia Spineli ,
Dimitris Mavridis ,
Deniz Orey ,
Franziska Richter ,
Myrto Samara ,
Corrado Barbui ,
Rolf R Engel ,
John R Geddes ,
Werner Kissling ,
Marko Paul Stapf ,
Bettina Lässig ,
Georgia Salanti ,
John M Davis
Sep 14 2013
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Abstract
The question of which antipsychotic drug should be preferred for the treatment of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a hierarchy based on the randomised evidence. We aimed to integrate the available evidence to create hierarchies of the comparative efficacy, risk of all-cause discontinuation, and major side-effects of antipsychotic drugs.