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      Measuring the patient response to dialysis therapy: hemodiafiltration and clinical trials.

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      Kidney international

      Elsevier BV

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          Abstract

          There is a strong biological plausibility for benefit from removal of larger uremic toxins and increasing positive clinical experience with hemodiafiltration. However, evidence supporting hemodiafiltration is not definitive with studies that are often limited by serious methodological shortcomings. Morena et al. show that hemodiafiltration may prevent intradialytic hypotension, albeit in a study that also has some shortcomings. Ongoing research for hemodiafiltration is still needed through high-quality clinical trials that adhere to standards for clinical trial conduct and reporting.

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          Author and article information

          Journal
          Kidney Int.
          Kidney international
          Elsevier BV
          1523-1755
          0085-2538
          Jun 2017
          : 91
          : 6
          Affiliations
          [1 ] Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Department of Renal Medicine, Counties Manukau District Health Board, Auckland, New Zealand; Therapeutic Area, Baxter Healthcare (Asia) Pty. Ltd., Singapore. Electronic address: mrmarshall@middlemore.co.nz.
          Article
          S0085-2538(17)30159-X
          10.1016/j.kint.2017.02.024
          28501302

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