7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Chemotherapy-Induced Peripheral Neuropathy: A Current Review

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect experienced by patients receiving treatment for cancer. Approximately 30–40% of patients treated with neurotoxic chemotherapy will develop CIPN and there is considerable variability in its severity between patients. It is often sensory-predominant with pain and can lead to long-term morbidity in survivors. The prevalence and burden of CIPN late effects will likely increase as cancer survival rates continue to improve. In this review, we discuss the approach to peripheral neuropathy in patients with cancer and address the clinical phenotypes and pathomechanisms of specific neurotoxic chemotherapeutic agents.

          Related collections

          Author and article information

          Journal
          7707449
          656
          Ann Neurol
          Ann. Neurol.
          Annals of neurology
          0364-5134
          1531-8249
          14 May 2017
          05 June 2017
          June 2017
          05 June 2018
          : 81
          : 6
          : 772-781
          Affiliations
          [1 ]Department of Neurology, Mayo Clinic, Rochester, MN, USA
          [2 ]Ludwig Boltzmann Institute for Experimental und Clinical Traumatology, Vienna, Austria
          [3 ]Department of Neurology, Medical University of Vienna, Austria
          Author notes
          Corresponding Author: Nathan P. Staff, M.D., Ph.D., Mayo Clinic, 200 First Street SW, Rochester, MN 55905, 507-284-8491 (phone), 507-284-4074 (fax), staff.nathan@ 123456mayo.edu
          Article
          PMC5656281 PMC5656281 5656281 nihpa874907
          10.1002/ana.24951
          5656281
          28486769
          Categories
          Article

          Comments

          Comment on this article