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      RefSeq microbial genomes database: new representation and annotation strategy

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          Abstract

          The source of the microbial genomic sequences in the RefSeq collection is the set of primary sequence records submitted to the International Nucleotide Sequence Database public archives. These can be accessed through the Entrez search and retrieval system at http://www.ncbi.nlm.nih.gov/genome. Next-generation sequencing has enabled researchers to perform genomic sequencing at rates that were unimaginable in the past. Microbial genomes can now be sequenced in a matter of hours, which has led to a significant increase in the number of assembled genomes deposited in the public archives. This huge increase in DNA sequence data presents new challenges for the annotation, analysis and visualization bioinformatics tools. New strategies have been developed for the annotation and representation of reference genomes and sequence variations derived from population studies and clinical outbreaks.

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          Author and article information

          Journal
          Nucleic Acids Res
          Nucleic Acids Res
          nar
          nar
          Nucleic Acids Research
          Oxford University Press
          0305-1048
          1362-4962
          January 2014
          7 December 2013
          7 December 2013
          : 42
          : D1 , Database issue
          : D553-D559
          Affiliations
          National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38A 8600 Rockville Pike, Bethesda, MD 20894, USA
          Author notes
          *To whom correspondence should be addressed. Tel: +11 301 435 5756; Fax: +11 301 402 9651; Email: tatiana@ 123456ncbi.nlm.nih.gov
          Article
          gkt1274
          10.1093/nar/gkt1274
          3965038
          24316578
          © Crown copyright 2013.
          Page count
          Pages: 7
          Categories
          IV. Viruses, bacteria, protozoa and fungi
          Custom metadata
          1 January 2014

          Genetics

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