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      Acidosis and Urinary Calcium Excretion: Insights from Genetic Disorders

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          Abstract

          Metabolic acidosis is associated with increased urinary calcium excretion and related sequelae, including nephrocalcinosis and nephrolithiasis. The increased urinary calcium excretion induced by metabolic acidosis predominantly results from increased mobilization of calcium out of bone and inhibition of calcium transport processes within the renal tubule. The mechanisms whereby acid alters the integrity and stability of bone have been examined extensively in the published literature. Here, after briefly reviewing this literature, we consider the effects of acid on calcium transport in the renal tubule and then discuss why not all gene defects that cause renal tubular acidosis are associated with hypercalciuria and nephrocalcinosis.

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          Author and article information

          Journal
          J Am Soc Nephrol
          J. Am. Soc. Nephrol
          jnephrol
          jnephrol
          ASN
          Journal of the American Society of Nephrology : JASN
          American Society of Nephrology
          1046-6673
          1533-3450
          December 2016
          28 July 2016
          : 27
          : 12
          : 3511-3520
          Affiliations
          Departments of [* ]Pediatrics and
          []Physiology, University of Alberta, Edmonton, Canada;
          []Institut National de la Santé et de la Recherche Médicale U970, Paris Centre de Recherche Cardiovasculaire, Université Paris Descartes, Sorbonne Paris Cité, Paris, France;
          [§ ]Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Demark; and
          []Department of Physiologie, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France
          Author notes
          Correspondence: Dr. R. Todd Alexander, Department of Pediatrics, 4-585 Edmonton Clinic, Health Academy, 11405– 87 Ave, University of Alberta, Edmonton, AB T6G 2R7, Canada. Email: todd2@ 123456ualberta.ca
          Article
          PMC5118493 PMC5118493 5118493 2016030305
          10.1681/ASN.2016030305
          5118493
          27468975
          5561f61d-4172-497e-95db-3bda94267b8a
          Copyright © 2016 by the American Society of Nephrology
          History
          Page count
          Figures: 1, Tables: 1, Equations: 0, References: 134, Pages: 10
          Categories
          Up Front Matters
          Brief Reviews
          Custom metadata
          December 2016

          renal tubular acidosis,hypercalciuria,calcium,chronic metabolic acidosis

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