Growth Hormone and Bone

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Abstract

Bone and mineral metabolism is regulated by numerous hormones and local growth factors. Growth hormone (GH), directly and/or indirectly through local IGF<sub>1</sub> and IGF<sub>2</sub> production, stimulates bone turnover as it increases osteoblast number and function. It also stimulates bone resorption through unknown mechanisms. GH (by IGFO stimulates the renal 25-hydroxyvitamin D-1α-hydroxylase activity and therefore enhances calcium and phosphate absorption in the intestine. It also increases the maximal renal tubular reabsorption of phosphate. The overall effect of GH on bone therefore seems beneficial as bone mass is increased together with the lean body mass. Large excess of GH, however, also increases the risk of osteoarthritis and has other serious metabolic side effects, so that its place in the treatment/prevention of osteoporosis is yet to be defined.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5552-4

ISBN: 978-3-318-01983-4

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1991

Publication date (Print): 1991

Publication date (Electronic): 02 December 2008

Volume: 36

Issue: Suppl 1

Pages: 49-55

Affiliations

Catholic University of Leuven, Laboratory of Experimental Medicine and Endocrinology, Leuven, Belgium

Article

Publisher ID: 182189 Other ID: Horm Res 1991;36:49–55

DOI: 10.1159/000182189

PubMed ID: 1806485

SO-VID: 5565ffe6-c415-4333-919a-19ac83b82902

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Pages: 7

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