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Antisynthetase syndrome pathogenesis : knowledge and uncertainties
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Abstract
<p class="first" id="d502949e95">Antisynthetase syndrome (ASyS) is an acquired myopathy
characterized by the presence
of myositis-specific autoantibodies directed against tRNA-synthetases. ASyS is potentially
life threatening due to lung involvement and treatment remains a challenge to date.
With symptoms not limited to muscles but also involving lung, skin and joints, ASyS
appears specific and has a particular pathogenesis, different from the other inflammatory
myopathies. This review is intended to discuss the current understanding of ASyS pathogenesis,
pointing its current knowledge and also the crucial prospects that may lead to critical
improvement of ASyS care.
</p>