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Recent advances in microRNA-mediated gene regulation in chronic lymphocytic leukemia.

Clinical biochemistry

metabolism, genetics, RNA, Neoplasm, MicroRNAs, pathology, Leukemia, Lymphocytic, Chronic, B-Cell, Humans, Hematopoietic Stem Cells, Gene Expression Regulation, Leukemic, Cell Differentiation, Animals

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      Abstract

      Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world and is a very clinically heterogeneous disease for which better prognostic biomarkers are needed. Current prognostic markers exhibit both biological and technical limitations. MicroRNAs (miRNAs) are small endogenous, non-coding 22-nucleotide regulatory RNAs that have been shown to modulate hematopoietic lineage differentiation and play important gene-regulatory roles in disease processes. In this manuscript, we review miRNA biology and the association of specific miRNAs with CLL. Copyright © 2013. Published by Elsevier Inc.

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      Journal
      10.1016/j.clinbiochem.2013.03.007
      23518313

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