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      Incidence of Hyponatremia with High-Dose Trimethoprim-Sulfamethoxazole Exposure

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      The American Journal of Medicine

      Elsevier BV

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          Abstract

          Trimethoprim-sulfamethoxazole (TMP-SMX) is a commonly prescribed antibiotic used at high doses for treatment of pneumocystis pneumonia and other infections. Trimethoprim is structurally related to the potassium-sparing diuretic amiloride and has been associated with hyperkalemia and hyponatremia through blocking of epithelial sodium channels in the distal nephron. The incidence of hyponatremia in hospitalized patients treated with high-dose TMP-SMX is unknown.

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          Author and article information

          Journal
          The American Journal of Medicine
          The American Journal of Medicine
          Elsevier BV
          00029343
          December 2016
          December 2016
          : 129
          : 12
          : 1322-1328
          Article
          10.1016/j.amjmed.2016.07.012
          27542610
          © 2016

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