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      Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

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          Abstract

          Elevated glucose levels impair islet function and survival, and it has been proposed that intraislet expression of IL-1beta contributes to glucotoxicity.

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          Author and article information

          Journal
          J Clin Endocrinol Metab
          The Journal of clinical endocrinology and metabolism
          The Endocrine Society
          0021-972X
          0021-972X
          Oct 2008
          : 93
          : 10
          Affiliations
          [1 ] Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland. marianne.boeni@usz.ch
          Article
          jc.2008-0396
          10.1210/jc.2008-0396
          2579638
          18664535
          55965f5f-1353-4850-8f62-c472bd557203
          History

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