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      Effects of Renal Nerves on Renal Hemodynamics


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          Renal nerves were stimulated either directly (loop electrodes) or indirectly (bilateral carotid occlusion with maintenance of control blood pressure) in anesthetized dogs to determine the effects on renal blood flow (RBF), glomerular filtration rate (GFR), sodium excretion (UNaV), and intrarenal distribution of blood flow (microsphere method). Direct nerve stimulation decreased RBF 20% in 9 of 10 dogs; but GFR, UNaV, and intrarenal distribution of blood flow did not change significantly. Carotid occlusion decreased RBF in 9 of 10 dogs. There was a 22% fall in RBF for the whole group, GFR decreased 33%, and UNaV decreased from 0.39 to 0.17 µEq/min/g (p < 0.05). A small (8%) decrease in midcortical fractional flow (p < 0.05) after carotid occlusion was the only distributional flow change observed. The results disclosed no relationship between changes in sodium excretion and changes in total RBF, GFR, or intrarenal distribution of blood flow following nerve stimulation. These studies also indicate that the renal effects of carotid occlusion are probably not mediated by renal nerve stimulation alone.

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          Author and article information

          S. Karger AG
          28 November 2008
          : 14
          : 3-4
          : 246-256
          Departments of Internal Medicine, Temple University Health Sciences Center, Philadelphia, Pa., and University of Arizona College of Medicine, and Veterans Administration Hospital, Tucson, Ariz.
          180454 Nephron 1975;14:246–256
          © 1975 S. Karger AG, Basel

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          : 26 September 1973
          : 24 July 1974
          Page count
          Pages: 11
          Original Paper

          Cardiovascular Medicine,Nephrology
          Direct renal nerve stimulation,Carotid occlusion,Sodium excretion,Intrarenal distribution of blood flow,Microsphere method


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