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      Effects of Renal Nerves on Renal Hemodynamics

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          Abstract

          Renal nerves were stimulated either directly (loop electrodes) or indirectly (bilateral carotid occlusion with maintenance of control blood pressure) in anesthetized dogs to determine the effects on renal blood flow (RBF), glomerular filtration rate (GFR), sodium excretion (UNaV), and intrarenal distribution of blood flow (microsphere method). Direct nerve stimulation decreased RBF 20% in 9 of 10 dogs; but GFR, UNaV, and intrarenal distribution of blood flow did not change significantly. Carotid occlusion decreased RBF in 9 of 10 dogs. There was a 22% fall in RBF for the whole group, GFR decreased 33%, and UNaV decreased from 0.39 to 0.17 µEq/min/g (p < 0.05). A small (8%) decrease in midcortical fractional flow (p < 0.05) after carotid occlusion was the only distributional flow change observed. The results disclosed no relationship between changes in sodium excretion and changes in total RBF, GFR, or intrarenal distribution of blood flow following nerve stimulation. These studies also indicate that the renal effects of carotid occlusion are probably not mediated by renal nerve stimulation alone.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1975
          1975
          28 November 2008
          : 14
          : 3-4
          : 246-256
          Affiliations
          Departments of Internal Medicine, Temple University Health Sciences Center, Philadelphia, Pa., and University of Arizona College of Medicine, and Veterans Administration Hospital, Tucson, Ariz.
          Article
          180454 Nephron 1975;14:246–256
          10.1159/000180454
          124020
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 11
          Categories
          Original Paper

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