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      Involvement of the mt1 melatonin receptor in human breast cancer

      , , , , , ,
      Cancer Letters
      Elsevier BV

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          Abstract

          Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mt1 receptor, but not the MT2 receptor, is expressed in human breast tumor cell lines, and melatonin-induced growth suppression can be mimicked by the mt1 and MT2 agonist, AMMTC, and blocked by the antagonist, CBPT. RORalpha receptors are also expressed in MCF-7 breast cancer cells and the putative RORalpha agonist CPG-52608 inhibits MCF-7 cell growth but with a very different dose-response than melatonin. Finally, melatonin and AMMTC, but not CPG-52608, can repress RORalpha transcriptional activity in MCF-7 cells.

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          Author and article information

          Journal
          Cancer Letters
          Cancer Letters
          Elsevier BV
          03043835
          May 2002
          May 2002
          : 179
          : 2
          : 141-150
          Article
          10.1016/S0304-3835(01)00873-4
          11888668
          55a68123-20f1-4195-ab0c-a6320573eb5d
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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