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      Effect of Postnatal Malnutrition on Plasma Proteins and Growth Hormone in the Rat 1


      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone, Malnutrition, Growth retardation

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          Dietary restriction of rats during the suckling period is known to result in irreversible growth stunting, which cannot be corrected even by ample supply of food after weaning. In order to determine whether growth hormone (GH) deficiency might play a role in this permanent growth failure, circulating GH concentrations were assayed in postnatally malnourished rats following 10 days of nutritional rehabilitation. The significantly lower plasma GH values observed in the restricted animals as compared to a control group suggests a causal relationship between GH deficiency and the persistent retarding effect of the early nutritional insult. The experimental model employed in this study closely resembles human infantile marasmus. However, the regulation of GH secretion in the rat differs from that seen in primate species. Therefore, extrapolation of these findings to marasmic infants cannot be made without reservation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 5
          : 3
          : 167-172
          Department of Pediatrics and Rogoff-Wellcome Trust Medical Research Laboratories, Beilinson Medical Center, Tel Aviv University Medical School, Petah Tikva, and Department of Medicine, Northwestern University School of Medicine, Chicago, Ill.
          178627 Horm Res 1974;5:167–172
          © 1974 S. Karger AG, Basel

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          Pages: 6


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