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Abstract
Material extracted and partially purified from human cerebrospinal fluid (CSF) is
capable of: a, inhibiting [3H]ouabain binding to rat brain synaptosomes; b, inhibiting
the activity of purified pig kidney Na+,K+-ATPase; and c, inhibiting ouabain sensitive
induced 86Rb influx to tissue cultured fibroblasts. These results demonstrate the
existence of an 'ouabain like' compound (OLC) in human CSF, and are consistent with
the hypothesis of the function of this compound as a neuromodulator.